TY - CHAP
T1 - Why hasn't eliminating acute rejection improved graft survival?
AU - Tantravahi, Jogi Raju
AU - Womer, Karl L.
AU - Kaplan, Bruce
PY - 2007/5/11
Y1 - 2007/5/11
N2 - Although patients with end-stage renal disease can be maintained with dialysis therapy, the superiority of patient survival with renal transplantation makes transplantation the preferred method of renal replacement. Potent immunosuppressive therapies, particularly calcineurin inhibitors, have greatly reduced the incidence of acute rejection. However, long-term allograft survival remains limited. We discuss the impact of acute rejection on long-term allograft survival and discuss other factors leading to late allograft loss, including calcineurin inhibitor toxicity, chronic allograft nephropathy, and BK virus nephropathy, as well as donor and recipient factors associated with long-term allograft loss.
AB - Although patients with end-stage renal disease can be maintained with dialysis therapy, the superiority of patient survival with renal transplantation makes transplantation the preferred method of renal replacement. Potent immunosuppressive therapies, particularly calcineurin inhibitors, have greatly reduced the incidence of acute rejection. However, long-term allograft survival remains limited. We discuss the impact of acute rejection on long-term allograft survival and discuss other factors leading to late allograft loss, including calcineurin inhibitor toxicity, chronic allograft nephropathy, and BK virus nephropathy, as well as donor and recipient factors associated with long-term allograft loss.
KW - Allograft survival
KW - BK virus nephropathy
KW - Calcineurin inhibitor toxicity
KW - Chronic allograft nephropathy
KW - Donor and recipient factors
KW - Kidney transplantation
UR - http://www.scopus.com/inward/record.url?scp=34047171006&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34047171006&partnerID=8YFLogxK
U2 - 10.1146/annurev.med.58.061705.145143
DO - 10.1146/annurev.med.58.061705.145143
M3 - Chapter
C2 - 17002551
AN - SCOPUS:34047171006
SN - 0824305582
SN - 9780824305581
T3 - Annual Review of Medicine
SP - 369
EP - 385
BT - Annual Review of Medicine
A2 - Caskey, null
A2 - Austin, null
A2 - Hoxie, null
ER -