Whose hypothesis? Ciphering, sectorials, D lesions, freckles and the operation of Stigler's Law

Research output: Contribution to journalArticle

Abstract

Common references to the famous two-hit hypothesis of tumorigenesis are pervasively erroneous, and the recited tenets of this model vary enormously. Exploration of the history of this model reveals a rich philosophical progression that profited from perceptive observations, clever musings, and rediscoveries by many investigators over a period of decades. The current work is intended to raise the appreciation for this rich history and to address some of the more common errors.

Original languageEnglish (US)
Pages (from-to)571-581
Number of pages11
JournalCancer Biology and Therapy
Volume1
Issue number5
DOIs
StatePublished - Sep 2002
Externally publishedYes

Fingerprint

Melanosis
History
Carcinogenesis
Research Personnel

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Molecular Medicine
  • Pharmacology

Cite this

Whose hypothesis? Ciphering, sectorials, D lesions, freckles and the operation of Stigler's Law. / Kern, Scott E.

In: Cancer Biology and Therapy, Vol. 1, No. 5, 09.2002, p. 571-581.

Research output: Contribution to journalArticle

@article{d5bc5a4fe6684545b16082d435edb5a8,
title = "Whose hypothesis? Ciphering, sectorials, D lesions, freckles and the operation of Stigler's Law",
abstract = "Common references to the famous two-hit hypothesis of tumorigenesis are pervasively erroneous, and the recited tenets of this model vary enormously. Exploration of the history of this model reveals a rich philosophical progression that profited from perceptive observations, clever musings, and rediscoveries by many investigators over a period of decades. The current work is intended to raise the appreciation for this rich history and to address some of the more common errors.",
author = "Kern, {Scott E}",
year = "2002",
month = "9",
doi = "10.4161/cbt.1.5.225",
language = "English (US)",
volume = "1",
pages = "571--581",
journal = "Cancer Biology and Therapy",
issn = "1538-4047",
publisher = "Landes Bioscience",
number = "5",

}

TY - JOUR

T1 - Whose hypothesis? Ciphering, sectorials, D lesions, freckles and the operation of Stigler's Law

AU - Kern, Scott E

PY - 2002/9

Y1 - 2002/9

N2 - Common references to the famous two-hit hypothesis of tumorigenesis are pervasively erroneous, and the recited tenets of this model vary enormously. Exploration of the history of this model reveals a rich philosophical progression that profited from perceptive observations, clever musings, and rediscoveries by many investigators over a period of decades. The current work is intended to raise the appreciation for this rich history and to address some of the more common errors.

AB - Common references to the famous two-hit hypothesis of tumorigenesis are pervasively erroneous, and the recited tenets of this model vary enormously. Exploration of the history of this model reveals a rich philosophical progression that profited from perceptive observations, clever musings, and rediscoveries by many investigators over a period of decades. The current work is intended to raise the appreciation for this rich history and to address some of the more common errors.

UR - http://www.scopus.com/inward/record.url?scp=1542671859&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1542671859&partnerID=8YFLogxK

U2 - 10.4161/cbt.1.5.225

DO - 10.4161/cbt.1.5.225

M3 - Article

C2 - 12496492

AN - SCOPUS:1542671859

VL - 1

SP - 571

EP - 581

JO - Cancer Biology and Therapy

JF - Cancer Biology and Therapy

SN - 1538-4047

IS - 5

ER -