Whose hypothesis? Ciphering, sectorials, D lesions, freckles and the operation of Stigler's Law

Research output: Contribution to journalArticlepeer-review

Abstract

Common references to the famous two-hit hypothesis of tumorigenesis are pervasively erroneous, and the recited tenets of this model vary enormously. Exploration of the history of this model reveals a rich philosophical progression that profited from perceptive observations, clever musings, and rediscoveries by many investigators over a period of decades. The current work is intended to raise the appreciation for this rich history and to address some of the more common errors.

Original languageEnglish (US)
Pages (from-to)571-581
Number of pages11
JournalCancer Biology and Therapy
Volume1
Issue number5
DOIs
StatePublished - Sep 2002
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Medicine
  • Oncology
  • Pharmacology
  • Cancer Research

Fingerprint

Dive into the research topics of 'Whose hypothesis? Ciphering, sectorials, D lesions, freckles and the operation of Stigler's Law'. Together they form a unique fingerprint.

Cite this