Whole slide images for primary diagnostics in dermatopathology: A feasibility study

Shaimaa Al-Janabi, André Huisman, Aryan Vink, Roos J. Leguit, G. Johan A Offerhaus, Fiebo J W Ten Kate, Marijke R. Van Dijk, Paul J. Van Diest

Research output: Contribution to journalArticle

Abstract

Background: During the last decade, whole slide images (WSI) have been used in many areas of pathology such as teaching, research, digital archiving, teleconsultation and quality assurance testing. However, WSI have not regularly been used for routine diagnosis, because of the lack of validation studies. Aim: To test the validity of using WSI for primary diagnosis of skin diseases. Materials and methods: 100 skin biopsies and resections which had been diagnosed light microscopically one year previously were scanned at 203 magnification, and rediagnosed by six pathologists (every pathologist assessed his own cases), having the original clinical information available, but blinded to the original diagnoses. The WSI diagnoses were compared to the initial light microscopy diagnosis and classified as concordant, slightly discordant (without clinical consequences) or discordant. Results: The light microscopy and the WSI based diagnosis were concordant in 94% of the cases. The light microscopy and WSI diagnosis were slightly discordant in 6% of the cases. For one of the slightly discrepant cases the WSI diagnosis was considered better, while the original diagnosis was preferred for the other five cases. There were no discordant cases with clinical or prognostic implications. Conclusion: Primary histopathological diagnosis of skin biopsies and resections can be done digitally using WSI.

Original languageEnglish (US)
Pages (from-to)152-158
Number of pages7
JournalJournal of Clinical Pathology
Volume65
Issue number2
DOIs
StatePublished - Feb 2012
Externally publishedYes

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Feasibility Studies
Light
Microscopy
Remote Consultation
Biopsy
Skin
Validation Studies
Skin Diseases
Teaching
Pathology

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Al-Janabi, S., Huisman, A., Vink, A., Leguit, R. J., Offerhaus, G. J. A., Ten Kate, F. J. W., ... Van Diest, P. J. (2012). Whole slide images for primary diagnostics in dermatopathology: A feasibility study. Journal of Clinical Pathology, 65(2), 152-158. https://doi.org/10.1136/jclinpath-2011-200277

Whole slide images for primary diagnostics in dermatopathology : A feasibility study. / Al-Janabi, Shaimaa; Huisman, André; Vink, Aryan; Leguit, Roos J.; Offerhaus, G. Johan A; Ten Kate, Fiebo J W; Van Dijk, Marijke R.; Van Diest, Paul J.

In: Journal of Clinical Pathology, Vol. 65, No. 2, 02.2012, p. 152-158.

Research output: Contribution to journalArticle

Al-Janabi, S, Huisman, A, Vink, A, Leguit, RJ, Offerhaus, GJA, Ten Kate, FJW, Van Dijk, MR & Van Diest, PJ 2012, 'Whole slide images for primary diagnostics in dermatopathology: A feasibility study', Journal of Clinical Pathology, vol. 65, no. 2, pp. 152-158. https://doi.org/10.1136/jclinpath-2011-200277
Al-Janabi S, Huisman A, Vink A, Leguit RJ, Offerhaus GJA, Ten Kate FJW et al. Whole slide images for primary diagnostics in dermatopathology: A feasibility study. Journal of Clinical Pathology. 2012 Feb;65(2):152-158. https://doi.org/10.1136/jclinpath-2011-200277
Al-Janabi, Shaimaa ; Huisman, André ; Vink, Aryan ; Leguit, Roos J. ; Offerhaus, G. Johan A ; Ten Kate, Fiebo J W ; Van Dijk, Marijke R. ; Van Diest, Paul J. / Whole slide images for primary diagnostics in dermatopathology : A feasibility study. In: Journal of Clinical Pathology. 2012 ; Vol. 65, No. 2. pp. 152-158.
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