Whole-Organ Genomic Characterization of Mucosal Field Effects Initiating Bladder Carcinogenesis

Tadeusz Majewski, Hui Yao, Jolanta Bondaruk, Woonbok Chung, Sangkyou Lee, June Goo Lee, Shizhen Zhang, David Cogdell, Guoliang Yang, Woonyoung Choi, Colin Dinney, H. Barton Grossman, Christopher Logothetis, Steven E. Scherer, Charles C. Guo, Li Zhang, Peng Wei, John N. Weinstein, Jean Pierre Issa, Keith BaggerlyDavid J. McConkey, Bogdan Czerniak

Research output: Contribution to journalArticle

Abstract

Majewski et al. report that methylation changes suppressing innate immunity and dysregulating Ras-related pathways initiate bladder carcinogenesis.

Original languageEnglish (US)
Pages (from-to)2241-2256.e4
JournalCell Reports
Volume26
Issue number8
DOIs
StatePublished - Feb 19 2019

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Keywords

  • DNA copy alterations
  • DNA methylation
  • Whole-organ map
  • bladder cancer
  • clonal expansion
  • clonal origins
  • field effect
  • founder mutation
  • gene signature
  • urothelial carcinoma

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Majewski, T., Yao, H., Bondaruk, J., Chung, W., Lee, S., Lee, J. G., Zhang, S., Cogdell, D., Yang, G., Choi, W., Dinney, C., Grossman, H. B., Logothetis, C., Scherer, S. E., Guo, C. C., Zhang, L., Wei, P., Weinstein, J. N., Issa, J. P., ... Czerniak, B. (2019). Whole-Organ Genomic Characterization of Mucosal Field Effects Initiating Bladder Carcinogenesis. Cell Reports, 26(8), 2241-2256.e4. https://doi.org/10.1016/j.celrep.2019.01.095