Whole-genome association analysis of treatment response in obsessive-compulsive disorder

H. Qin, Jack Samuels, Youfa Wang, Y. Zhu, Marco Grados, Mark A Riddle, B. D. Greenberg, J. A. Knowles, A. J. Fyer, J. T. McCracken, D. L. Murphy, S. A. Rasmussen, B. A. Cullen, J. Piacentini, D. Geller, S. E. Stewart, D. Pauls, Oscar J Bienvenu, Fernando S Goes, Brion MaherAnn E Pulver, David Valle, C. Lange, M. Mattheisen, N. C. McLaughlin, K. Y. Liang, E. L. Nurmi, K. D. Askland, Gerald Nestadt, Y. Y. Shugart

Research output: Contribution to journalArticle

Abstract

Up to 30% of patients with obsessive-compulsive disorder (OCD) exhibit an inadequate response to serotonin reuptake inhibitors (SRIs). To date, genetic predictors of OCD treatment response have not been systematically investigated using genome-wide association study (GWAS). To identify specific genetic variations potentially influencing SRI response, we conducted a GWAS study in 804 OCD patients with information on SRI response. SRI response was classified as 'response' (n=514) or 'non-response' (n=290), based on self-report. We used the more powerful Quasi-Likelihood Score Test (the MQLS test) to conduct a genome-wide association test correcting for relatedness, and then used an adjusted logistic model to evaluate the effect size of the variants in probands. The top single-nucleotide polymorphism (SNP) was rs17162912 (P=1.76 × 10 -8), which is near the DISP1 gene on 1q41-q42, a microdeletion region implicated in neurological development. The other six SNPs showing suggestive evidence of association (P

Original languageEnglish (US)
Pages (from-to)270-276
Number of pages7
JournalMolecular Psychiatry
Volume21
Issue number2
DOIs
StatePublished - Feb 1 2016

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Genome-Wide Association Study
Obsessive-Compulsive Disorder
Serotonin Uptake Inhibitors
Single Nucleotide Polymorphism
Therapeutics
Self Report
Logistic Models
Genome
Genes

ASJC Scopus subject areas

  • Molecular Biology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

Cite this

Whole-genome association analysis of treatment response in obsessive-compulsive disorder. / Qin, H.; Samuels, Jack; Wang, Youfa; Zhu, Y.; Grados, Marco; Riddle, Mark A; Greenberg, B. D.; Knowles, J. A.; Fyer, A. J.; McCracken, J. T.; Murphy, D. L.; Rasmussen, S. A.; Cullen, B. A.; Piacentini, J.; Geller, D.; Stewart, S. E.; Pauls, D.; Bienvenu, Oscar J; Goes, Fernando S; Maher, Brion; Pulver, Ann E; Valle, David; Lange, C.; Mattheisen, M.; McLaughlin, N. C.; Liang, K. Y.; Nurmi, E. L.; Askland, K. D.; Nestadt, Gerald; Shugart, Y. Y.

In: Molecular Psychiatry, Vol. 21, No. 2, 01.02.2016, p. 270-276.

Research output: Contribution to journalArticle

Qin, H, Samuels, J, Wang, Y, Zhu, Y, Grados, M, Riddle, MA, Greenberg, BD, Knowles, JA, Fyer, AJ, McCracken, JT, Murphy, DL, Rasmussen, SA, Cullen, BA, Piacentini, J, Geller, D, Stewart, SE, Pauls, D, Bienvenu, OJ, Goes, FS, Maher, B, Pulver, AE, Valle, D, Lange, C, Mattheisen, M, McLaughlin, NC, Liang, KY, Nurmi, EL, Askland, KD, Nestadt, G & Shugart, YY 2016, 'Whole-genome association analysis of treatment response in obsessive-compulsive disorder', Molecular Psychiatry, vol. 21, no. 2, pp. 270-276. https://doi.org/10.1038/mp.2015.32
Qin, H. ; Samuels, Jack ; Wang, Youfa ; Zhu, Y. ; Grados, Marco ; Riddle, Mark A ; Greenberg, B. D. ; Knowles, J. A. ; Fyer, A. J. ; McCracken, J. T. ; Murphy, D. L. ; Rasmussen, S. A. ; Cullen, B. A. ; Piacentini, J. ; Geller, D. ; Stewart, S. E. ; Pauls, D. ; Bienvenu, Oscar J ; Goes, Fernando S ; Maher, Brion ; Pulver, Ann E ; Valle, David ; Lange, C. ; Mattheisen, M. ; McLaughlin, N. C. ; Liang, K. Y. ; Nurmi, E. L. ; Askland, K. D. ; Nestadt, Gerald ; Shugart, Y. Y. / Whole-genome association analysis of treatment response in obsessive-compulsive disorder. In: Molecular Psychiatry. 2016 ; Vol. 21, No. 2. pp. 270-276.
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