Whole-cell vaccines

Danijela Jelovac; Leisha A. Emens

doi:10.1007/978-1-4419-0717-2_148

Whole-cell vaccines

Danijela Jelovac, Leisha A. Emens

School of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Therapeutic cancer vaccines aim to generate tumor immunity through coordinated cell- and antibody-mediated responses that ultimately result in highly specific and potent T cells capable of destroying cancers. Cancer vaccines have unique advantages compared to most other cancer therapeutics, with a high degree of specificity for tumor cells relative to normal tissues, a highly favorable side-effect profile, and the potential for a long-lasting treatment effect due to immunologic memory.

Original language	English (US)
Title of host publication	Cancer Therapeutic Targets
Publisher	Springer New York
Pages	561-574
Number of pages	14
Volume	1-2
ISBN (Electronic)	9781441907172
ISBN (Print)	9781441907165
DOIs	https://doi.org/10.1007/978-1-4419-0717-2_148
State	Published - Jan 1 2017

Keywords

Chemotherapy
Combination immunotherapy
Immune response
Immunotherapy
Monoclonal antibody
Whole-cell vaccine

ASJC Scopus subject areas

General Medicine
General Biochemistry, Genetics and Molecular Biology
Pharmacology, Toxicology and Pharmaceutics(all)

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10.1007/978-1-4419-0717-2_148

Cite this

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AB - Therapeutic cancer vaccines aim to generate tumor immunity through coordinated cell- and antibody-mediated responses that ultimately result in highly specific and potent T cells capable of destroying cancers. Cancer vaccines have unique advantages compared to most other cancer therapeutics, with a high degree of specificity for tumor cells relative to normal tissues, a highly favorable side-effect profile, and the potential for a long-lasting treatment effect due to immunologic memory.

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KW - Immune response

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Whole-cell vaccines

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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