Whole brain blood flow and oxygen metabolism in the rat after halothane anesthesia

A. Gjedde, B. Hindfeldt

Research output: Contribution to journalArticle

Abstract

A recent modification of the Kety Schmidt wash out technique for 133xenon was used to measure whole brain blood flow (CBF) and oxygen consumption (CMR(O2)) 1 to 4 hours after termination of halothane anesthesia in 15 Wistar rats. In this 3 hour experimental period, mean CBF and CMR(O2) were reduced to 29 and 43% of control values, respectively. CBF and CMR(O2) determined at the beginning and end of the experimental period were not significantly different from each other. Cerebral venous O2 tension was significantly higher than in the control group, supporting recent suggestions of a primary, intrinsic effect of halothane on the homeostatic control of this variable. It is concluded that halothane is not useful for cerebral metabolic studies in the rat.

Original languageEnglish (US)
Pages (from-to)310-315
Number of pages6
JournalActa Anaesthesiologica Scandinavica
Volume19
Issue number4
StatePublished - 1975
Externally publishedYes

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Halothane
Anesthesia
Oxygen
Brain
Oxygen Consumption
Wistar Rats
Control Groups

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Whole brain blood flow and oxygen metabolism in the rat after halothane anesthesia. / Gjedde, A.; Hindfeldt, B.

In: Acta Anaesthesiologica Scandinavica, Vol. 19, No. 4, 1975, p. 310-315.

Research output: Contribution to journalArticle

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