WHO multicentre study for the development of growth standards from fetal life to childhood: The fetal component

Mario Merialdi, Mariana Widmer, Ahmet M. Gülmezoglu, Hany Abdel-Aleem, George Bega, Alexandra Benachi, Guillermo Carroli, Jose G. Cecatti, Anke Diemert, Rogelio Gonzalez, Kurt Hecher, Lisa N. Jensen, Synnøve L. Johnsen, Torvid Kiserud, Alka Kriplani, Pisake Lumbiganon, Ann Tabor, Sameera A. Talegawkar, Antoinette Tshefu, Daniel WojdylaLawrence Platt

Research output: Contribution to journalArticle

Abstract

Background: In 2006 WHO presented the infant and child growth charts suggested for universal application. However, major determinants for perinatal outcomes and postnatal growth are laid down during antenatal development. Accordingly, monitoring fetal growth in utero by ultrasonography is important both for clinical and scientific reasons. The currently used fetal growth references are derived mainly from North American and European population and may be inappropriate for international use, given possible variances in the growth rates of fetuses from different ethnic population groups. WHO has, therefore, made it a high priority to establish charts of optimal fetal growth that can be recommended worldwide.Methods: This is a multi-national study for the development of fetal growth standards for international application by assessing fetal growth in populations of different ethnic and geographic backgrounds. The study will select pregnant women of high-middle socioeconomic status with no obvious environmental constraints on growth (adequate nutritional status, non-smoking), and normal pregnancy history with no complications likely to affect fetal growth. The study will be conducted in centres from ten developing and industrialized countries: Argentina, Brazil, Democratic Republic of Congo, Denmark, Egypt, France, Germany, India, Norway, and Thailand. At each centre, 140 pregnant women will be recruited between 8 + 0 and 12 + 6 weeks of gestation. Subsequently, visits for fetal biometry will be scheduled at 14, 18, 24, 28, 32, 36, and 40 weeks (+/- 1 week) to be performed by trained ultrasonographers.The main outcome of the proposed study will be the development of fetal growth standards (either global or population specific) for international applications.Discussion: The data from this study will be incorporated into obstetric practice and national health policies at country level in coordination with the activities presently conducted by WHO to implement the use of the Child Growth Standards.

Original languageEnglish (US)
Article number157
JournalBMC Pregnancy and Childbirth
Volume14
Issue number1
DOIs
StatePublished - May 2 2014

Fingerprint

Fetal Development
Growth and Development
Multicenter Studies
Growth
Pregnant Women
Growth Charts
Population
Biometry
Democratic Republic of the Congo
Reproductive History
Egypt
Argentina
Thailand
Denmark
Norway
Health Policy
Nutritional Status
Population Groups
Ethnic Groups
Developed Countries

Keywords

  • Child development
  • Fetal growth
  • Growth standards
  • Ultrasound

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Medicine(all)

Cite this

Merialdi, M., Widmer, M., Gülmezoglu, A. M., Abdel-Aleem, H., Bega, G., Benachi, A., ... Platt, L. (2014). WHO multicentre study for the development of growth standards from fetal life to childhood: The fetal component. BMC Pregnancy and Childbirth, 14(1), [157]. https://doi.org/10.1186/1471-2393-14-157

WHO multicentre study for the development of growth standards from fetal life to childhood : The fetal component. / Merialdi, Mario; Widmer, Mariana; Gülmezoglu, Ahmet M.; Abdel-Aleem, Hany; Bega, George; Benachi, Alexandra; Carroli, Guillermo; Cecatti, Jose G.; Diemert, Anke; Gonzalez, Rogelio; Hecher, Kurt; Jensen, Lisa N.; Johnsen, Synnøve L.; Kiserud, Torvid; Kriplani, Alka; Lumbiganon, Pisake; Tabor, Ann; Talegawkar, Sameera A.; Tshefu, Antoinette; Wojdyla, Daniel; Platt, Lawrence.

In: BMC Pregnancy and Childbirth, Vol. 14, No. 1, 157, 02.05.2014.

Research output: Contribution to journalArticle

Merialdi, M, Widmer, M, Gülmezoglu, AM, Abdel-Aleem, H, Bega, G, Benachi, A, Carroli, G, Cecatti, JG, Diemert, A, Gonzalez, R, Hecher, K, Jensen, LN, Johnsen, SL, Kiserud, T, Kriplani, A, Lumbiganon, P, Tabor, A, Talegawkar, SA, Tshefu, A, Wojdyla, D & Platt, L 2014, 'WHO multicentre study for the development of growth standards from fetal life to childhood: The fetal component', BMC Pregnancy and Childbirth, vol. 14, no. 1, 157. https://doi.org/10.1186/1471-2393-14-157
Merialdi, Mario ; Widmer, Mariana ; Gülmezoglu, Ahmet M. ; Abdel-Aleem, Hany ; Bega, George ; Benachi, Alexandra ; Carroli, Guillermo ; Cecatti, Jose G. ; Diemert, Anke ; Gonzalez, Rogelio ; Hecher, Kurt ; Jensen, Lisa N. ; Johnsen, Synnøve L. ; Kiserud, Torvid ; Kriplani, Alka ; Lumbiganon, Pisake ; Tabor, Ann ; Talegawkar, Sameera A. ; Tshefu, Antoinette ; Wojdyla, Daniel ; Platt, Lawrence. / WHO multicentre study for the development of growth standards from fetal life to childhood : The fetal component. In: BMC Pregnancy and Childbirth. 2014 ; Vol. 14, No. 1.
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AU - Abdel-Aleem, Hany

AU - Bega, George

AU - Benachi, Alexandra

AU - Carroli, Guillermo

AU - Cecatti, Jose G.

AU - Diemert, Anke

AU - Gonzalez, Rogelio

AU - Hecher, Kurt

AU - Jensen, Lisa N.

AU - Johnsen, Synnøve L.

AU - Kiserud, Torvid

AU - Kriplani, Alka

AU - Lumbiganon, Pisake

AU - Tabor, Ann

AU - Talegawkar, Sameera A.

AU - Tshefu, Antoinette

AU - Wojdyla, Daniel

AU - Platt, Lawrence

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