White paper on guidelines concerning enteric nervous system stem cell therapy for enteric neuropathies

Alan J. Burns; Allan M. Goldstein; Donald F. Newgreen; Lincon Stamp; Karl Herbert Schäfer; Marco Metzger; Ryo Hotta; Heather M. Young; Peter W. Andrews; Nikhil Thapar; Jaime Belkind-Gerson; Nadege Bondurand; Joel C. Bornstein; Wood Yee Chan; Kathryn Cheah; Michael D. Gershon; Robert O. Heuckeroth; Robert M.W. Hofstra; Lothar Just; Raj P. Kapur; Sebastian K. King; Conor J. McCann; Nandor Nagy; Elly Ngan; Florian Obermayr; Vassilis Pachnis; Pankaj J. Pasricha; Mai Har Sham; Paul Tam; Pieter Vanden Berghe

doi:10.1016/j.ydbio.2016.04.001

White paper on guidelines concerning enteric nervous system stem cell therapy for enteric neuropathies

Alan J. Burns, Allan M. Goldstein, Donald F. Newgreen, Lincon Stamp, Karl Herbert Schäfer, Marco Metzger, Ryo Hotta, Heather M. Young, Peter W. Andrews, Nikhil Thapar, Jaime Belkind-Gerson, Nadege Bondurand, Joel C. Bornstein, Wood Yee Chan, Kathryn Cheah, Michael D. Gershon, Robert O. Heuckeroth, Robert M.W. Hofstra, Lothar Just, Raj P. KapurSebastian K. King, Conor J. McCann, Nandor Nagy, Elly Ngan, Florian Obermayr, Vassilis Pachnis, Pankaj J. Pasricha, Mai Har Sham, Paul Tam, Pieter Vanden Berghe

School of Medicine

Research output: Contribution to journal › Review article › peer-review

65 Scopus citations

Abstract

Over the last 20 years, there has been increasing focus on the development of novel stem cell based therapies for the treatment of disorders and diseases affecting the enteric nervous system (ENS) of the gastrointestinal tract (so-called enteric neuropathies). Here, the idea is that ENS progenitor/stem cells could be transplanted into the gut wall to replace the damaged or absent neurons and glia of the ENS. This White Paper sets out experts’ views on the commonly used methods and approaches to identify, isolate, purify, expand and optimize ENS stem cells, transplant them into the bowel, and assess transplant success, including restoration of gut function. We also highlight obstacles that must be overcome in order to progress from successful preclinical studies in animal models to ENS stem cell therapies in the clinic.

Original language	English (US)
Pages (from-to)	229-251
Number of pages	23
Journal	Developmental biology
Volume	417
Issue number	2
DOIs	https://doi.org/10.1016/j.ydbio.2016.04.001
State	Published - Sep 15 2016

Keywords

Cell replacement therapy
Enteric nervous system
Enteric neuropathies
Hirschsprung disease
Stem cells

ASJC Scopus subject areas

Molecular Biology
Developmental Biology
Cell Biology

Access to Document

10.1016/j.ydbio.2016.04.001

Cite this

Burns, A. J., Goldstein, A. M., Newgreen, D. F., Stamp, L., Schäfer, K. H., Metzger, M., Hotta, R., Young, H. M., Andrews, P. W., Thapar, N., Belkind-Gerson, J., Bondurand, N., Bornstein, J. C., Chan, W. Y., Cheah, K., Gershon, M. D., Heuckeroth, R. O., Hofstra, R. M. W., Just, L., ... Vanden Berghe, P. (2016). White paper on guidelines concerning enteric nervous system stem cell therapy for enteric neuropathies. Developmental biology, 417(2), 229-251. https://doi.org/10.1016/j.ydbio.2016.04.001

Burns, AJ, Goldstein, AM, Newgreen, DF, Stamp, L, Schäfer, KH, Metzger, M, Hotta, R, Young, HM, Andrews, PW, Thapar, N, Belkind-Gerson, J, Bondurand, N, Bornstein, JC, Chan, WY, Cheah, K, Gershon, MD, Heuckeroth, RO, Hofstra, RMW, Just, L, Kapur, RP, King, SK, McCann, CJ, Nagy, N, Ngan, E, Obermayr, F, Pachnis, V, Pasricha, PJ, Sham, MH, Tam, P & Vanden Berghe, P 2016, 'White paper on guidelines concerning enteric nervous system stem cell therapy for enteric neuropathies', Developmental biology, vol. 417, no. 2, pp. 229-251. https://doi.org/10.1016/j.ydbio.2016.04.001

@article{0b7ae55b7a2c43b58cb59273f89756f7,

title = "White paper on guidelines concerning enteric nervous system stem cell therapy for enteric neuropathies",

abstract = "Over the last 20 years, there has been increasing focus on the development of novel stem cell based therapies for the treatment of disorders and diseases affecting the enteric nervous system (ENS) of the gastrointestinal tract (so-called enteric neuropathies). Here, the idea is that ENS progenitor/stem cells could be transplanted into the gut wall to replace the damaged or absent neurons and glia of the ENS. This White Paper sets out experts{\textquoteright} views on the commonly used methods and approaches to identify, isolate, purify, expand and optimize ENS stem cells, transplant them into the bowel, and assess transplant success, including restoration of gut function. We also highlight obstacles that must be overcome in order to progress from successful preclinical studies in animal models to ENS stem cell therapies in the clinic.",

keywords = "Cell replacement therapy, Enteric nervous system, Enteric neuropathies, Hirschsprung disease, Stem cells",

author = "Burns, {Alan J.} and Goldstein, {Allan M.} and Newgreen, {Donald F.} and Lincon Stamp and Sch{\"a}fer, {Karl Herbert} and Marco Metzger and Ryo Hotta and Young, {Heather M.} and Andrews, {Peter W.} and Nikhil Thapar and Jaime Belkind-Gerson and Nadege Bondurand and Bornstein, {Joel C.} and Chan, {Wood Yee} and Kathryn Cheah and Gershon, {Michael D.} and Heuckeroth, {Robert O.} and Hofstra, {Robert M.W.} and Lothar Just and Kapur, {Raj P.} and King, {Sebastian K.} and McCann, {Conor J.} and Nandor Nagy and Elly Ngan and Florian Obermayr and Vassilis Pachnis and Pasricha, {Pankaj J.} and Sham, {Mai Har} and Paul Tam and {Vanden Berghe}, Pieter",

note = "Publisher Copyright: {\textcopyright} 2016 The Authors",

year = "2016",

month = sep,

day = "15",

doi = "10.1016/j.ydbio.2016.04.001",

language = "English (US)",

volume = "417",

pages = "229--251",

journal = "Developmental biology",

issn = "0012-1606",

publisher = "Academic Press Inc.",

number = "2",

}

TY - JOUR

T1 - White paper on guidelines concerning enteric nervous system stem cell therapy for enteric neuropathies

AU - Burns, Alan J.

AU - Goldstein, Allan M.

AU - Newgreen, Donald F.

AU - Stamp, Lincon

AU - Schäfer, Karl Herbert

AU - Metzger, Marco

AU - Hotta, Ryo

AU - Young, Heather M.

AU - Andrews, Peter W.

AU - Thapar, Nikhil

AU - Belkind-Gerson, Jaime

AU - Bondurand, Nadege

AU - Bornstein, Joel C.

AU - Chan, Wood Yee

AU - Cheah, Kathryn

AU - Gershon, Michael D.

AU - Heuckeroth, Robert O.

AU - Hofstra, Robert M.W.

AU - Just, Lothar

AU - Kapur, Raj P.

AU - King, Sebastian K.

AU - McCann, Conor J.

AU - Nagy, Nandor

AU - Ngan, Elly

AU - Obermayr, Florian

AU - Pachnis, Vassilis

AU - Pasricha, Pankaj J.

AU - Sham, Mai Har

AU - Tam, Paul

AU - Vanden Berghe, Pieter

PY - 2016/9/15

Y1 - 2016/9/15

N2 - Over the last 20 years, there has been increasing focus on the development of novel stem cell based therapies for the treatment of disorders and diseases affecting the enteric nervous system (ENS) of the gastrointestinal tract (so-called enteric neuropathies). Here, the idea is that ENS progenitor/stem cells could be transplanted into the gut wall to replace the damaged or absent neurons and glia of the ENS. This White Paper sets out experts’ views on the commonly used methods and approaches to identify, isolate, purify, expand and optimize ENS stem cells, transplant them into the bowel, and assess transplant success, including restoration of gut function. We also highlight obstacles that must be overcome in order to progress from successful preclinical studies in animal models to ENS stem cell therapies in the clinic.

AB - Over the last 20 years, there has been increasing focus on the development of novel stem cell based therapies for the treatment of disorders and diseases affecting the enteric nervous system (ENS) of the gastrointestinal tract (so-called enteric neuropathies). Here, the idea is that ENS progenitor/stem cells could be transplanted into the gut wall to replace the damaged or absent neurons and glia of the ENS. This White Paper sets out experts’ views on the commonly used methods and approaches to identify, isolate, purify, expand and optimize ENS stem cells, transplant them into the bowel, and assess transplant success, including restoration of gut function. We also highlight obstacles that must be overcome in order to progress from successful preclinical studies in animal models to ENS stem cell therapies in the clinic.

KW - Cell replacement therapy

KW - Enteric nervous system

KW - Enteric neuropathies

KW - Hirschsprung disease

KW - Stem cells

UR - http://www.scopus.com/inward/record.url?scp=84964222425&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84964222425&partnerID=8YFLogxK

U2 - 10.1016/j.ydbio.2016.04.001

DO - 10.1016/j.ydbio.2016.04.001

M3 - Review article

C2 - 27059883

AN - SCOPUS:84964222425

SN - 0012-1606

VL - 417

SP - 229

EP - 251

JO - Developmental biology

JF - Developmental biology

IS - 2

ER -

White paper on guidelines concerning enteric nervous system stem cell therapy for enteric neuropathies

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this