White matter microstructural differences linked to left perisylvian language network in children with dyslexia

Sheryl L. Rimrodt, Daniel J. Peterson, Martha B. Denckla, Walter E. Kaufmann, Laurie E. Cutting

Research output: Contribution to journalArticle

Abstract

Studies of dyslexia using diffusion tensor imaging (DTI) have reported fractional anisotropy (FA) differences in left inferior frontal gyrus (LIFG) and left temporo-parietal white matter, suggesting that impaired reading is associated with atypical white matter microstructure in these regions. These anomalies might reflect abnormalities in the left perisylvian language network, long implicated in dyslexia. While DTI investigations frequently report analyses on multiple tensor-derived measures (e.g., FA, orientation, tractography), it is uncommon to integrate analyses to examine the relationships between atypical findings. For the present study, semi-automated techniques were applied to DTI data in an integrated fashion to examine white matter microstructure in 14 children with dyslexia and 17 typically developing readers (ages 7-16 years). Correlations of DTI metrics (FA and fiber orientation) to reading skill (accuracy and speed) and to probabilistic tractography maps of the left perisylvian language tracts were examined. Consistent with previous reports, our findings suggest FA decreases in dyslexia in LIFG and left temporo-parietal white matter. The LIFG FA finding overlaps an area showing differences in fiber orientation in an anterior left perisylvian language pathway. Additionally, a positive correlation of FA to reading speed was found in a posterior circuit previously associated with activation on functional imaging during reading tasks. Overall, integrating results from several complementary semi-automated analyses reveals evidence linking atypical white matter microstructure in dyslexia to atypical fiber orientation in circuits implicated in reading including the left perisylvian language network.

Original languageEnglish (US)
Pages (from-to)739-749
Number of pages11
JournalCortex
Volume46
Issue number6
DOIs
StatePublished - Jun 1 2010

Keywords

  • Diffusion tensor imaging
  • Dyslexia
  • Fractional anisotropy
  • Left inferior frontal gyrus
  • Perisylvian language network

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience

Fingerprint Dive into the research topics of 'White matter microstructural differences linked to left perisylvian language network in children with dyslexia'. Together they form a unique fingerprint.

  • Cite this