White matter integrity and behavioral activation in healthy subjects

Jiansong Xu, Hedy Kober, Kathleen M. Carroll, Bruce J. Rounsaville, Godfrey D. Pearlson, Marc N. Potenza

Research output: Contribution to journalArticle

Abstract

Individual differences in behavioral inhibition and behavioral activation may place certain people at greater risk for neuropsychiatric disorders and engagement in risky behaviors. Therefore, studying the neural correlates of behavioral inhibition and activation may help us understand neural mechanisms underlying risk behaviors in both clinical and non-clinical populations. To investigate, we assessed the relationships between white matter integrity and measures of behavioral inhibition and behavioral activation in 51 healthy participants using diffusion tensor imaging (DTI) and the Behavioral Inhibition System/Behavioral Activation System (BIS/BAS) scale. Scores on the Fun-Seeking subscale of the BAS positively correlated with DTI fractional anisotropy in the left corona radiata and adjacent superior longitudinal fasciculus, and with mean diffusivity in the left inferior longitudinal fasciculus and inferior fronto-occipital fasciculus after controlling for age, gender, and education. These findings suggest that the integrity of white matter connecting extensive brain regions implicated in self-control and the processing of rewards and emotions are associated with individual differences in the motivation for seeking and participating in fun and novel experiences.

Original languageEnglish (US)
Pages (from-to)994-1002
Number of pages9
JournalHuman Brain Mapping
Volume33
Issue number4
DOIs
StatePublished - Apr 2012
Externally publishedYes

Fingerprint

Healthy Volunteers
Diffusion Tensor Imaging
Individuality
Anisotropy
Risk-Taking
Reward
Motivation
Emotions
Education
White Matter
Inhibition (Psychology)
Brain
Population

Keywords

  • Behavioral activation
  • Behavioral inhibition
  • Cognitive control
  • DTI
  • Neuroimaging
  • Self-control

ASJC Scopus subject areas

  • Clinical Neurology
  • Anatomy
  • Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Xu, J., Kober, H., Carroll, K. M., Rounsaville, B. J., Pearlson, G. D., & Potenza, M. N. (2012). White matter integrity and behavioral activation in healthy subjects. Human Brain Mapping, 33(4), 994-1002. https://doi.org/10.1002/hbm.21275

White matter integrity and behavioral activation in healthy subjects. / Xu, Jiansong; Kober, Hedy; Carroll, Kathleen M.; Rounsaville, Bruce J.; Pearlson, Godfrey D.; Potenza, Marc N.

In: Human Brain Mapping, Vol. 33, No. 4, 04.2012, p. 994-1002.

Research output: Contribution to journalArticle

Xu, J, Kober, H, Carroll, KM, Rounsaville, BJ, Pearlson, GD & Potenza, MN 2012, 'White matter integrity and behavioral activation in healthy subjects', Human Brain Mapping, vol. 33, no. 4, pp. 994-1002. https://doi.org/10.1002/hbm.21275
Xu J, Kober H, Carroll KM, Rounsaville BJ, Pearlson GD, Potenza MN. White matter integrity and behavioral activation in healthy subjects. Human Brain Mapping. 2012 Apr;33(4):994-1002. https://doi.org/10.1002/hbm.21275
Xu, Jiansong ; Kober, Hedy ; Carroll, Kathleen M. ; Rounsaville, Bruce J. ; Pearlson, Godfrey D. ; Potenza, Marc N. / White matter integrity and behavioral activation in healthy subjects. In: Human Brain Mapping. 2012 ; Vol. 33, No. 4. pp. 994-1002.
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