White matter hyperintensity detected by magnetic resonance imaging and lithium response in bipolar disorder: A preliminary observation

Tadafumi Kato; Kumiko Fujii; Atsushi Kamiya; Nobumasa Kato

doi:10.1046/j.1440-1819.2000.00646.x

White matter hyperintensity detected by magnetic resonance imaging and lithium response in bipolar disorder: A preliminary observation

Tadafumi Kato, Kumiko Fujii, Atsushi Kamiya, Nobumasa Kato

Research output: Contribution to journal › Article › peer-review

Abstract

The possible relationship between deep white matter hyperintensity (WMHI) lesions detected by magnetic resonance imaging and response to lithium was examined in 16 patients with bipolar disorder who had been under maintenance treatment with lithium for more than 1 year. Bipolar patients who had higher scores of WMHI responded significantly better to lithium (r = 0.57, P < 0.05) than did those who had lower scores. This preliminary result suggests that the presence of WMHI may be associated with a better response to lithium.

Original language	English (US)
Pages (from-to)	117-120
Number of pages	4
Journal	Psychiatry and Clinical Neurosciences
Volume	54
Issue number	1
DOIs	https://doi.org/10.1046/j.1440-1819.2000.00646.x
State	Published - Feb 2000
Externally published	Yes

Keywords

Bipolar disorder
Brain
Lithium
Magnetic resonance imaging
Treatment response

ASJC Scopus subject areas

Neuroscience(all)
Neurology
Clinical Neurology
Psychiatry and Mental health

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AU - Kato, Nobumasa

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AB - The possible relationship between deep white matter hyperintensity (WMHI) lesions detected by magnetic resonance imaging and response to lithium was examined in 16 patients with bipolar disorder who had been under maintenance treatment with lithium for more than 1 year. Bipolar patients who had higher scores of WMHI responded significantly better to lithium (r = 0.57, P < 0.05) than did those who had lower scores. This preliminary result suggests that the presence of WMHI may be associated with a better response to lithium.

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KW - Treatment response

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White matter hyperintensity detected by magnetic resonance imaging and lithium response in bipolar disorder: A preliminary observation

Abstract

Keywords

ASJC Scopus subject areas

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