White matter hyperintensity detected by magnetic resonance imaging and lithium response in bipolar disorder: A preliminary observation

Tadafumi Kato, Kumiko Fujii, Atsushi Kamiya, Nobumasa Kato

Research output: Contribution to journalArticlepeer-review

Abstract

The possible relationship between deep white matter hyperintensity (WMHI) lesions detected by magnetic resonance imaging and response to lithium was examined in 16 patients with bipolar disorder who had been under maintenance treatment with lithium for more than 1 year. Bipolar patients who had higher scores of WMHI responded significantly better to lithium (r = 0.57, P < 0.05) than did those who had lower scores. This preliminary result suggests that the presence of WMHI may be associated with a better response to lithium.

Original languageEnglish (US)
Pages (from-to)117-120
Number of pages4
JournalPsychiatry and Clinical Neurosciences
Volume54
Issue number1
DOIs
StatePublished - Feb 2000
Externally publishedYes

Keywords

  • Bipolar disorder
  • Brain
  • Lithium
  • Magnetic resonance imaging
  • Treatment response

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health

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