White matter grade and ventricular volume on brain MRI as markers of longevity in the cardiovascular health study

Lewis H. Kuller, Alice M. Arnold, W. T. Longstreth, Teri A. Manolio, Daniel H. O'Leary, Gregory L. Burke, Linda P. Fried, Anne B. Newman

Research output: Contribution to journalArticlepeer-review

Abstract

High white matter grade (WMG) on magnetic resonance imaging (MRI) is a risk factor for dementia, stroke and disability. Higher ventricular size is a marker of brain "atrophy." In the Cardiovascular Health Study (CHS) (n = 3245) mean age 75 years, 50% black and 40% men, we evaluated WM and ventricular grade (VG), total, cardiovascular and noncardiovascular mortality and longevity before and after adjusting for numerous determinants of longevity over an approximate 10-12 years of follow-up. A low WMG and VG was a marker for low total, cardiovascular and noncardiovascular mortality and for increased longevity over 10+ years of follow-up. We estimated that a 75-year-old with WMG below median would have about a 5-6 years greater longevity and for VG about 3 years, than above the median even after adjustment for numerous risk factors. Low WMG and VG on MRI is a powerful determinant of long-term survival among older individuals.

Original languageEnglish (US)
Pages (from-to)1307-1315
Number of pages9
JournalNeurobiology of Aging
Volume28
Issue number9
DOIs
StatePublished - Sep 1 2007

Keywords

  • Aging
  • Cardiovascular disease
  • MRI
  • Survival
  • Ventricular size
  • White matter

ASJC Scopus subject areas

  • Neuroscience(all)
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

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