White matter changes linked to visual recovery after nerve decompression

David A. Paul, Elon Gaffin-Cahn, Eric B. Hintz, Giscard J. Adeclat, Tong Zhu, Zoë R. Williams, G. Edward Vates, Bradford Z. Mahon

Research output: Contribution to journalArticle

Abstract

The relationship between the integrity of white matter tracts and cortical function in the human brain remains poorly understood. We investigate reversible white matter injury, in this case patients with compression of the optic chiasm by pituitary gland tumors, to study the structural and functional changes that attend spontaneous recovery of cortical function and visual abilities after surgical removal of the tumor and subsequent decompression of the nerves. We show that compression of the optic chiasm led to demyelination of the optic tracts, which reversed as quickly as 4 weeks after nerve decompression. Furthermore, variability across patients in the severity of demyelination in the optic tracts predicted visual ability and functional activity in early cortical visual areas. Preoperative measurements of myelination in the optic tracts predicted the magnitude of visual recovery after surgery. These data indicate that rapid regeneration of myelin in the human brain is a component of the normalization of cortical activity, and ultimately the recovery of sensory and cognitive function, after nerve decompression. More generally, our findings demonstrate the use of diffusion tensor imaging as an in vivo measure of myelination in the human brain.

Original languageEnglish (US)
JournalScience Translational Medicine
Volume6
Issue number266
DOIs
StatePublished - Dec 10 2014
Externally publishedYes

Fingerprint

Decompression
Optic Chiasm
Aptitude
Recovery of Function
Demyelinating Diseases
Brain
Diffusion Tensor Imaging
Pituitary Neoplasms
Pituitary Gland
Myelin Sheath
Cognition
Regeneration
Wounds and Injuries
Optic Tract
White Matter
Neoplasms

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Paul, D. A., Gaffin-Cahn, E., Hintz, E. B., Adeclat, G. J., Zhu, T., Williams, Z. R., ... Mahon, B. Z. (2014). White matter changes linked to visual recovery after nerve decompression. Science Translational Medicine, 6(266). https://doi.org/10.1126/scitranslmed.3010798

White matter changes linked to visual recovery after nerve decompression. / Paul, David A.; Gaffin-Cahn, Elon; Hintz, Eric B.; Adeclat, Giscard J.; Zhu, Tong; Williams, Zoë R.; Vates, G. Edward; Mahon, Bradford Z.

In: Science Translational Medicine, Vol. 6, No. 266, 10.12.2014.

Research output: Contribution to journalArticle

Paul, DA, Gaffin-Cahn, E, Hintz, EB, Adeclat, GJ, Zhu, T, Williams, ZR, Vates, GE & Mahon, BZ 2014, 'White matter changes linked to visual recovery after nerve decompression', Science Translational Medicine, vol. 6, no. 266. https://doi.org/10.1126/scitranslmed.3010798
Paul, David A. ; Gaffin-Cahn, Elon ; Hintz, Eric B. ; Adeclat, Giscard J. ; Zhu, Tong ; Williams, Zoë R. ; Vates, G. Edward ; Mahon, Bradford Z. / White matter changes linked to visual recovery after nerve decompression. In: Science Translational Medicine. 2014 ; Vol. 6, No. 266.
@article{169eef4e1c7b42de9d79fc24d125d18c,
title = "White matter changes linked to visual recovery after nerve decompression",
abstract = "The relationship between the integrity of white matter tracts and cortical function in the human brain remains poorly understood. We investigate reversible white matter injury, in this case patients with compression of the optic chiasm by pituitary gland tumors, to study the structural and functional changes that attend spontaneous recovery of cortical function and visual abilities after surgical removal of the tumor and subsequent decompression of the nerves. We show that compression of the optic chiasm led to demyelination of the optic tracts, which reversed as quickly as 4 weeks after nerve decompression. Furthermore, variability across patients in the severity of demyelination in the optic tracts predicted visual ability and functional activity in early cortical visual areas. Preoperative measurements of myelination in the optic tracts predicted the magnitude of visual recovery after surgery. These data indicate that rapid regeneration of myelin in the human brain is a component of the normalization of cortical activity, and ultimately the recovery of sensory and cognitive function, after nerve decompression. More generally, our findings demonstrate the use of diffusion tensor imaging as an in vivo measure of myelination in the human brain.",
author = "Paul, {David A.} and Elon Gaffin-Cahn and Hintz, {Eric B.} and Adeclat, {Giscard J.} and Tong Zhu and Williams, {Zo{\"e} R.} and Vates, {G. Edward} and Mahon, {Bradford Z.}",
year = "2014",
month = "12",
day = "10",
doi = "10.1126/scitranslmed.3010798",
language = "English (US)",
volume = "6",
journal = "Science Translational Medicine",
issn = "1946-6234",
publisher = "American Association for the Advancement of Science",
number = "266",

}

TY - JOUR

T1 - White matter changes linked to visual recovery after nerve decompression

AU - Paul, David A.

AU - Gaffin-Cahn, Elon

AU - Hintz, Eric B.

AU - Adeclat, Giscard J.

AU - Zhu, Tong

AU - Williams, Zoë R.

AU - Vates, G. Edward

AU - Mahon, Bradford Z.

PY - 2014/12/10

Y1 - 2014/12/10

N2 - The relationship between the integrity of white matter tracts and cortical function in the human brain remains poorly understood. We investigate reversible white matter injury, in this case patients with compression of the optic chiasm by pituitary gland tumors, to study the structural and functional changes that attend spontaneous recovery of cortical function and visual abilities after surgical removal of the tumor and subsequent decompression of the nerves. We show that compression of the optic chiasm led to demyelination of the optic tracts, which reversed as quickly as 4 weeks after nerve decompression. Furthermore, variability across patients in the severity of demyelination in the optic tracts predicted visual ability and functional activity in early cortical visual areas. Preoperative measurements of myelination in the optic tracts predicted the magnitude of visual recovery after surgery. These data indicate that rapid regeneration of myelin in the human brain is a component of the normalization of cortical activity, and ultimately the recovery of sensory and cognitive function, after nerve decompression. More generally, our findings demonstrate the use of diffusion tensor imaging as an in vivo measure of myelination in the human brain.

AB - The relationship between the integrity of white matter tracts and cortical function in the human brain remains poorly understood. We investigate reversible white matter injury, in this case patients with compression of the optic chiasm by pituitary gland tumors, to study the structural and functional changes that attend spontaneous recovery of cortical function and visual abilities after surgical removal of the tumor and subsequent decompression of the nerves. We show that compression of the optic chiasm led to demyelination of the optic tracts, which reversed as quickly as 4 weeks after nerve decompression. Furthermore, variability across patients in the severity of demyelination in the optic tracts predicted visual ability and functional activity in early cortical visual areas. Preoperative measurements of myelination in the optic tracts predicted the magnitude of visual recovery after surgery. These data indicate that rapid regeneration of myelin in the human brain is a component of the normalization of cortical activity, and ultimately the recovery of sensory and cognitive function, after nerve decompression. More generally, our findings demonstrate the use of diffusion tensor imaging as an in vivo measure of myelination in the human brain.

UR - http://www.scopus.com/inward/record.url?scp=84916920155&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84916920155&partnerID=8YFLogxK

U2 - 10.1126/scitranslmed.3010798

DO - 10.1126/scitranslmed.3010798

M3 - Article

C2 - 25504884

AN - SCOPUS:84916920155

VL - 6

JO - Science Translational Medicine

JF - Science Translational Medicine

SN - 1946-6234

IS - 266

ER -