Which Way Do We Go? Complex Interactions in Atopic Dermatitis Pathogenesis

Garrett J. Patrick, Nathan K. Archer, Lloyd S. Miller

Research output: Contribution to journalReview articlepeer-review

Abstract

Atopic dermatitis (AD) is a common, chronic, inflammatory skin condition characterized by recurrent and pruritic skin eruptions. Multiple factors contribute to the pathogenesis of AD, including skin barrier dysfunction, microbial dysbiosis, and immune dysregulation. Interactions among these factors form a complex, multidirectional network that can reinforce atopic skin disease but can also be ameliorated by targeted therapies. This review summarizes the complex interactions among contributing factors in AD and the implications on disease development and therapeutic interventions.

Original languageEnglish (US)
Pages (from-to)274-284
Number of pages11
JournalJournal of Investigative Dermatology
Volume141
Issue number2
DOIs
StatePublished - Feb 2021

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

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