Where to begin? The mechanism of translation initiation codon selection in eukaryotes

Mikkel A. Algire; Jon R. Lorsch

doi:10.1016/j.cbpa.2006.08.010

Where to begin? The mechanism of translation initiation codon selection in eukaryotes

Mikkel A. Algire, Jon R. Lorsch

Research output: Contribution to journal › Review article › peer-review

20 Scopus citations

Abstract

Selecting the codon at which to begin translation is a complicated event in an already complicated process. Many protein initiation factors (eIFs) have been implicated in start site selection, but the mechanistic details of their activities have remained obscure until recently. Biochemical and genetic studies of eIFs 1, 1A, 2 and 5 have suggested that the 43S pre-initiation complex exists in two conformations and that the changing interactions of the factors within the 43S pre-initiation complex in response to encountering an AUG codon regulates these conformations and, ultimately, the selection of the start codon.

Original language	English (US)
Pages (from-to)	480-486
Number of pages	7
Journal	Current Opinion in Chemical Biology
Volume	10
Issue number	5
DOIs	https://doi.org/10.1016/j.cbpa.2006.08.010
State	Published - Oct 2006
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry

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title = "Where to begin? The mechanism of translation initiation codon selection in eukaryotes",

abstract = "Selecting the codon at which to begin translation is a complicated event in an already complicated process. Many protein initiation factors (eIFs) have been implicated in start site selection, but the mechanistic details of their activities have remained obscure until recently. Biochemical and genetic studies of eIFs 1, 1A, 2 and 5 have suggested that the 43S pre-initiation complex exists in two conformations and that the changing interactions of the factors within the 43S pre-initiation complex in response to encountering an AUG codon regulates these conformations and, ultimately, the selection of the start codon.",

author = "Algire, {Mikkel A.} and Lorsch, {Jon R.}",

note = "Funding Information: We thank Alan Hinnebusch, Sarah Mitchell, Mike Acker, Sarah Kolitz and Julie Takacs for helpful comments on the manuscript. Work in the authors{\textquoteright} laboratory was funded by grants from NIH/NIGMS, American Cancer Society and American Heart Association.",

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T1 - Where to begin? The mechanism of translation initiation codon selection in eukaryotes

AU - Algire, Mikkel A.

AU - Lorsch, Jon R.

N1 - Funding Information: We thank Alan Hinnebusch, Sarah Mitchell, Mike Acker, Sarah Kolitz and Julie Takacs for helpful comments on the manuscript. Work in the authors’ laboratory was funded by grants from NIH/NIGMS, American Cancer Society and American Heart Association.

PY - 2006/10

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N2 - Selecting the codon at which to begin translation is a complicated event in an already complicated process. Many protein initiation factors (eIFs) have been implicated in start site selection, but the mechanistic details of their activities have remained obscure until recently. Biochemical and genetic studies of eIFs 1, 1A, 2 and 5 have suggested that the 43S pre-initiation complex exists in two conformations and that the changing interactions of the factors within the 43S pre-initiation complex in response to encountering an AUG codon regulates these conformations and, ultimately, the selection of the start codon.

AB - Selecting the codon at which to begin translation is a complicated event in an already complicated process. Many protein initiation factors (eIFs) have been implicated in start site selection, but the mechanistic details of their activities have remained obscure until recently. Biochemical and genetic studies of eIFs 1, 1A, 2 and 5 have suggested that the 43S pre-initiation complex exists in two conformations and that the changing interactions of the factors within the 43S pre-initiation complex in response to encountering an AUG codon regulates these conformations and, ultimately, the selection of the start codon.

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Where to begin? The mechanism of translation initiation codon selection in eukaryotes

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