When whorls collide: The development of hair patterns in frizzled 6 mutant mice

Yanshu Wang, Hao Chang, Jeremy Nathans

Research output: Contribution to journalArticle

Abstract

Surface appendages such as bristles, feathers and hairs exhibit both long- and short-range order. In the frizzled 6 null (Fz6-/-) mouse the orientations of the earliest born hair follicles are uncorrelated, but over time the follicles reorient to create patterns that are characterized by a high degree of local order. By quantifying follicle orientations over time, in both living and fixed tissues, we define the time course of local hair follicle refinement and the resulting evolution of a montage of competing patterns in Fz6-/- skin. We observe an apparently local process that within one week can organize a field of many tens of thousands of follicles, generating long-range order that extends over distances of more than one centimeter. Physical systems that undergo an analogous ordering of vector components suggest potential mechanisms that might apply to the patterning of hair follicles and related biological structures.

Original languageEnglish (US)
Pages (from-to)4091-4099
Number of pages9
JournalDevelopment
Volume137
Issue number23
DOIs
StatePublished - Dec 1 2010

Keywords

  • Frizzled 6
  • Hair pattern
  • Mouse
  • Planar cell polarity

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology

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