TY - JOUR
T1 - When neurogenesis encounters aging and disease
AU - Lazarov, Orly
AU - Mattson, Mark P.
AU - Peterson, Daniel A.
AU - Pimplikar, Sanjay W.
AU - van Praag, Henriette
PY - 2010/12
Y1 - 2010/12
N2 - In this review, we consider the evidence that a reduction in neurogenesis underlies aging-related cognitive deficits and impairments in disorders such as Alzheimer's disease (AD). The molecular and cellular alterations associated with impaired neurogenesis in the aging brain are discussed. Dysfunction of presenilin-1, misprocessing of amyloid precursor protein and toxic effects of hyperphosphorylated tau and β-amyloid probably contribute to impaired neurogenesis in AD. Because factors such as exercise, environmental enrichment and dietary energy restriction enhance neurogenesis, and protect against age-related cognitive decline and AD, knowledge of the underlying neurogenic signaling pathways could lead to novel therapeutic strategies for preserving brain function. In addition, manipulation of endogenous neural stem cells and stem cell transplantation, as stand-alone or adjunct treatments, seems promising.
AB - In this review, we consider the evidence that a reduction in neurogenesis underlies aging-related cognitive deficits and impairments in disorders such as Alzheimer's disease (AD). The molecular and cellular alterations associated with impaired neurogenesis in the aging brain are discussed. Dysfunction of presenilin-1, misprocessing of amyloid precursor protein and toxic effects of hyperphosphorylated tau and β-amyloid probably contribute to impaired neurogenesis in AD. Because factors such as exercise, environmental enrichment and dietary energy restriction enhance neurogenesis, and protect against age-related cognitive decline and AD, knowledge of the underlying neurogenic signaling pathways could lead to novel therapeutic strategies for preserving brain function. In addition, manipulation of endogenous neural stem cells and stem cell transplantation, as stand-alone or adjunct treatments, seems promising.
UR - http://www.scopus.com/inward/record.url?scp=78149470437&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78149470437&partnerID=8YFLogxK
U2 - 10.1016/j.tins.2010.09.003
DO - 10.1016/j.tins.2010.09.003
M3 - Article
C2 - 20961627
AN - SCOPUS:78149470437
SN - 0166-2236
VL - 33
SP - 569
EP - 579
JO - Trends in Neurosciences
JF - Trends in Neurosciences
IS - 12
ER -