When is prostate cancer really cancer?

David M. Berman, Jonathan I. Epstein

Research output: Contribution to journalReview articlepeer-review

Abstract

Several investigators have challenged the idea that low-grade cancers are a cause for concern, suggesting that the term cancer should not be applied to these tumors. This article reviews the defining features of cancer, and the diagnostic and prognostic classification systems currently used for prostate cancer. Logical, morphologic, and molecular evidence is presented to show that low-grade prostate cancers are correctly classified as cancer. The authors suggest, however, that 6 out of 10 on an aggressiveness scale is inappropriate for indolent cancer, and that a proposed reinterpretation of Gleason grading categories is a more logical way to address overtreatment.

Original languageEnglish (US)
Pages (from-to)339-346
Number of pages8
JournalUrologic Clinics of North America
Volume41
Issue number2
DOIs
StatePublished - May 2014

Keywords

  • Gleason grade
  • Low-grade cancer
  • PSA screening
  • Prostate cancer

ASJC Scopus subject areas

  • Urology

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