TY - JOUR
T1 - When does Huntington's disease begin?
AU - Campodonico, Jeffrey R.
AU - Aylward, Elizabeth H.
AU - Codori, Ann-Marie
AU - Young, Candace
AU - Krafft, Laura
AU - Magdalinski, Michael
AU - Ranen, Neal
AU - Slavney, Phillip R.
AU - Brandt, Jason
PY - 1998/9
Y1 - 1998/9
N2 - Recent studies have detected basal ganglia atrophy in clinically asymptomatic persons with the genetic mutation that causes Huntington's disease (HD). Whether reductions in caudate and putamen volume on MRI scans are associated with changes in cognitive and neurologic functioning was examined in 13 healthy adults with the IT-15 mutation. Reduced striatal volume was found to correlate with greater neurologic (largely motor) impairment, slower mental processing speed, and poorer verbal learning, although none of the participants met even liberal criteria for clinical diagnosis of HD. These correlations are strikingly similar to those observed in symptomatic HD patients, possibly reflecting the earliest manifestations of disease.
AB - Recent studies have detected basal ganglia atrophy in clinically asymptomatic persons with the genetic mutation that causes Huntington's disease (HD). Whether reductions in caudate and putamen volume on MRI scans are associated with changes in cognitive and neurologic functioning was examined in 13 healthy adults with the IT-15 mutation. Reduced striatal volume was found to correlate with greater neurologic (largely motor) impairment, slower mental processing speed, and poorer verbal learning, although none of the participants met even liberal criteria for clinical diagnosis of HD. These correlations are strikingly similar to those observed in symptomatic HD patients, possibly reflecting the earliest manifestations of disease.
KW - Cognitive tests
KW - Genetics
KW - Huntington's disease
KW - MRI scans
KW - Presymptomatic testing
UR - http://www.scopus.com/inward/record.url?scp=0031682198&partnerID=8YFLogxK
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U2 - 10.1017/S1355617798455061
DO - 10.1017/S1355617798455061
M3 - Article
C2 - 9745236
AN - SCOPUS:0031682198
VL - 4
SP - 467
EP - 473
JO - Journal of the International Neuropsychological Society
JF - Journal of the International Neuropsychological Society
SN - 1355-6177
IS - 5
ER -