When differentiation goes viral

Courtney M. Shirley, Richard F. Ambinder

Research output: Contribution to journalComment/debatepeer-review


In this issue of Blood, Vrzalikova et al present evidence that Epstein-Barr virus (EBV) infection leads to the down-regulation of BLIMP1α in primary germinal center (GC) B cells.1 BLIMP1 is a transcription factor encoded by the PRDM1 gene. It stops cell cycling and leads to terminal differentiation of B cells to plasma cells. The authors suggest that EBV inhibition of BLIMP1α expression serves to inhibit terminal differentiation of EBV-infected cells.

Original languageEnglish (US)
Pages (from-to)5790-5791
Number of pages2
Issue number22
StatePublished - Jun 2 2011

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology


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