TY - JOUR
T1 - When differentiation goes viral
AU - Shirley, Courtney M.
AU - Ambinder, Richard F.
PY - 2011/6/2
Y1 - 2011/6/2
N2 - In this issue of Blood, Vrzalikova et al present evidence that Epstein-Barr virus (EBV) infection leads to the down-regulation of BLIMP1α in primary germinal center (GC) B cells.1 BLIMP1 is a transcription factor encoded by the PRDM1 gene. It stops cell cycling and leads to terminal differentiation of B cells to plasma cells. The authors suggest that EBV inhibition of BLIMP1α expression serves to inhibit terminal differentiation of EBV-infected cells.
AB - In this issue of Blood, Vrzalikova et al present evidence that Epstein-Barr virus (EBV) infection leads to the down-regulation of BLIMP1α in primary germinal center (GC) B cells.1 BLIMP1 is a transcription factor encoded by the PRDM1 gene. It stops cell cycling and leads to terminal differentiation of B cells to plasma cells. The authors suggest that EBV inhibition of BLIMP1α expression serves to inhibit terminal differentiation of EBV-infected cells.
UR - http://www.scopus.com/inward/record.url?scp=79958004393&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79958004393&partnerID=8YFLogxK
U2 - 10.1182/blood-2011-04-344135
DO - 10.1182/blood-2011-04-344135
M3 - Comment/debate
C2 - 21636716
AN - SCOPUS:79958004393
SN - 0006-4971
VL - 117
SP - 5790
EP - 5791
JO - Blood
JF - Blood
IS - 22
ER -