Wheat gluten challenge in schizophrenic patients

S. G. Potkin; D. Weinberger; J. Kleinman; H. Nasrallah; D. Luchins; L. Bigelow; M. Linnoila; S. H. Fischer; T. D. Bjornsson; J. Carman; J. C. Gillin; R. J. Wyatt

doi:10.1176/ajp.138.9.1208

Wheat gluten challenge in schizophrenic patients

S. G. Potkin, D. Weinberger, J. Kleinman, H. Nasrallah, D. Luchins, L. Bigelow, M. Linnoila, S. H. Fischer, T. D. Bjornsson, J. Carman, J. C. Gillin, R. J. Wyatt

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

Eight chronic schizophrenic patients were maintained on a diet free of gluten, cereal grains, and milk (CM-F diet) and challanged in a double-blind manner with dietary wheat gluten and placebo. While on the CM-F diet, each patient received a daily challenge of 30 g of gluten for 5 weeks and a placebo challenge for 8 weeks. No deterioration in clinical status as measured by the BPRS was noted on gluten challenge. Serum α₁ acid glycoprotein measurement demonstrated no evidence of inflammatory response to gluten challenge. The data suggest that sensitivity to dietary gluten is not characteristic of young chronic schizophrenic patients.

Original language	English (US)
Pages (from-to)	1208-1211
Number of pages	4
Journal	Unknown Journal
Volume	138
Issue number	9
DOIs	https://doi.org/10.1176/ajp.138.9.1208
State	Published - 1981
Externally published	Yes

ASJC Scopus subject areas

Psychiatry and Mental health

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10.1176/ajp.138.9.1208

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title = "Wheat gluten challenge in schizophrenic patients",

abstract = "Eight chronic schizophrenic patients were maintained on a diet free of gluten, cereal grains, and milk (CM-F diet) and challanged in a double-blind manner with dietary wheat gluten and placebo. While on the CM-F diet, each patient received a daily challenge of 30 g of gluten for 5 weeks and a placebo challenge for 8 weeks. No deterioration in clinical status as measured by the BPRS was noted on gluten challenge. Serum α1 acid glycoprotein measurement demonstrated no evidence of inflammatory response to gluten challenge. The data suggest that sensitivity to dietary gluten is not characteristic of young chronic schizophrenic patients.",

author = "Potkin, {S. G.} and D. Weinberger and J. Kleinman and H. Nasrallah and D. Luchins and L. Bigelow and M. Linnoila and Fischer, {S. H.} and Bjornsson, {T. D.} and J. Carman and Gillin, {J. C.} and Wyatt, {R. J.}",

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doi = "10.1176/ajp.138.9.1208",

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T1 - Wheat gluten challenge in schizophrenic patients

AU - Potkin, S. G.

AU - Weinberger, D.

AU - Kleinman, J.

AU - Nasrallah, H.

AU - Luchins, D.

AU - Bigelow, L.

AU - Linnoila, M.

AU - Fischer, S. H.

AU - Bjornsson, T. D.

AU - Carman, J.

AU - Gillin, J. C.

AU - Wyatt, R. J.

PY - 1981

Y1 - 1981

N2 - Eight chronic schizophrenic patients were maintained on a diet free of gluten, cereal grains, and milk (CM-F diet) and challanged in a double-blind manner with dietary wheat gluten and placebo. While on the CM-F diet, each patient received a daily challenge of 30 g of gluten for 5 weeks and a placebo challenge for 8 weeks. No deterioration in clinical status as measured by the BPRS was noted on gluten challenge. Serum α1 acid glycoprotein measurement demonstrated no evidence of inflammatory response to gluten challenge. The data suggest that sensitivity to dietary gluten is not characteristic of young chronic schizophrenic patients.

AB - Eight chronic schizophrenic patients were maintained on a diet free of gluten, cereal grains, and milk (CM-F diet) and challanged in a double-blind manner with dietary wheat gluten and placebo. While on the CM-F diet, each patient received a daily challenge of 30 g of gluten for 5 weeks and a placebo challenge for 8 weeks. No deterioration in clinical status as measured by the BPRS was noted on gluten challenge. Serum α1 acid glycoprotein measurement demonstrated no evidence of inflammatory response to gluten challenge. The data suggest that sensitivity to dietary gluten is not characteristic of young chronic schizophrenic patients.

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Wheat gluten challenge in schizophrenic patients

Abstract

ASJC Scopus subject areas

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