What's in a trough? Therapeutic drug monitoring and antiretroviral regimens.

Research output: Contribution to journalArticle

Abstract

The benefits and toxicity of any drug are a function of the drug's concentration in the patient. Therapeutic drug monitoring (TDM), or drug concentration analysis, implies that a patient's drug concentration must fall within a certain range in order for the drug to be therapeutic. TDM requirements are described in a table. Researchers are looking at the relationship between antiretroviral drug concentrations and clinical outcome. There is no consensus regarding TDM use for antiretroviral drugs. An appendix includes text from the AIDS Clinical Trials Group Pharmacology Committee Position Paper on Therapeutic Drug Monitoring for Antiretroviral Drugs. The committee does not recommend using drug concentrations to change antiretroviral therapy in individual patients.

Original languageEnglish (US)
JournalThe Hopkins HIV report : a bimonthly newsletter for healthcare providers / Johns Hopkins University AIDS Service
Volume12
Issue number1
StatePublished - 2000
Externally publishedYes

Fingerprint

Drug Monitoring
Pharmaceutical Preparations
Drug-Related Side Effects and Adverse Reactions
Acquired Immunodeficiency Syndrome
Research Personnel
Clinical Trials
Pharmacology
Therapeutics

Cite this

@article{94b5047df3af4c8a81eb600310128f41,
title = "What's in a trough? Therapeutic drug monitoring and antiretroviral regimens.",
abstract = "The benefits and toxicity of any drug are a function of the drug's concentration in the patient. Therapeutic drug monitoring (TDM), or drug concentration analysis, implies that a patient's drug concentration must fall within a certain range in order for the drug to be therapeutic. TDM requirements are described in a table. Researchers are looking at the relationship between antiretroviral drug concentrations and clinical outcome. There is no consensus regarding TDM use for antiretroviral drugs. An appendix includes text from the AIDS Clinical Trials Group Pharmacology Committee Position Paper on Therapeutic Drug Monitoring for Antiretroviral Drugs. The committee does not recommend using drug concentrations to change antiretroviral therapy in individual patients.",
author = "Flexner, {Charles Williams}",
year = "2000",
language = "English (US)",
volume = "12",
journal = "The Hopkins HIV report : a bimonthly newsletter for healthcare providers / Johns Hopkins University AIDS Service",
issn = "1551-8396",
publisher = "Johns Hopkins University Press",
number = "1",

}

TY - JOUR

T1 - What's in a trough? Therapeutic drug monitoring and antiretroviral regimens.

AU - Flexner, Charles Williams

PY - 2000

Y1 - 2000

N2 - The benefits and toxicity of any drug are a function of the drug's concentration in the patient. Therapeutic drug monitoring (TDM), or drug concentration analysis, implies that a patient's drug concentration must fall within a certain range in order for the drug to be therapeutic. TDM requirements are described in a table. Researchers are looking at the relationship between antiretroviral drug concentrations and clinical outcome. There is no consensus regarding TDM use for antiretroviral drugs. An appendix includes text from the AIDS Clinical Trials Group Pharmacology Committee Position Paper on Therapeutic Drug Monitoring for Antiretroviral Drugs. The committee does not recommend using drug concentrations to change antiretroviral therapy in individual patients.

AB - The benefits and toxicity of any drug are a function of the drug's concentration in the patient. Therapeutic drug monitoring (TDM), or drug concentration analysis, implies that a patient's drug concentration must fall within a certain range in order for the drug to be therapeutic. TDM requirements are described in a table. Researchers are looking at the relationship between antiretroviral drug concentrations and clinical outcome. There is no consensus regarding TDM use for antiretroviral drugs. An appendix includes text from the AIDS Clinical Trials Group Pharmacology Committee Position Paper on Therapeutic Drug Monitoring for Antiretroviral Drugs. The committee does not recommend using drug concentrations to change antiretroviral therapy in individual patients.

UR - http://www.scopus.com/inward/record.url?scp=0033655648&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033655648&partnerID=8YFLogxK

M3 - Article

C2 - 11366318

AN - SCOPUS:0033655648

VL - 12

JO - The Hopkins HIV report : a bimonthly newsletter for healthcare providers / Johns Hopkins University AIDS Service

JF - The Hopkins HIV report : a bimonthly newsletter for healthcare providers / Johns Hopkins University AIDS Service

SN - 1551-8396

IS - 1

ER -