Abstract
In this issue of the JCI, a study by Cauwels and colleagues suggests a central role for eNOS, the endothelial isoform of nitric oxide synthase, as a mediator of anaphylaxis (see the related article beginning on page 2244). Why is an enzyme originally described as a physiological mediator of vascular homeostasis implicated in the spectacular vascular collapse that is characteristic of anaphylaxis? And is the eNOS involved in anaphylaxis necessarily exerting its effect solely in the vascular endothelium, or might this "endothelial enzyme" actually be playing a more fundamental role in an entirely different tissue? After all, what's in a name?
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2075-2078 |
| Number of pages | 4 |
| Journal | Journal of Clinical Investigation |
| Volume | 116 |
| Issue number | 8 |
| DOIs | |
| State | Published - Aug 1 2006 |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
What's in a name? eNOS and anaphylactic shock. / Lowenstein, Charles J.; Michel, Thomas.
In: Journal of Clinical Investigation, Vol. 116, No. 8, 01.08.2006, p. 2075-2078.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - What's in a name? eNOS and anaphylactic shock
AU - Lowenstein, Charles J.
AU - Michel, Thomas
PY - 2006/8/1
Y1 - 2006/8/1
N2 - In this issue of the JCI, a study by Cauwels and colleagues suggests a central role for eNOS, the endothelial isoform of nitric oxide synthase, as a mediator of anaphylaxis (see the related article beginning on page 2244). Why is an enzyme originally described as a physiological mediator of vascular homeostasis implicated in the spectacular vascular collapse that is characteristic of anaphylaxis? And is the eNOS involved in anaphylaxis necessarily exerting its effect solely in the vascular endothelium, or might this "endothelial enzyme" actually be playing a more fundamental role in an entirely different tissue? After all, what's in a name?
AB - In this issue of the JCI, a study by Cauwels and colleagues suggests a central role for eNOS, the endothelial isoform of nitric oxide synthase, as a mediator of anaphylaxis (see the related article beginning on page 2244). Why is an enzyme originally described as a physiological mediator of vascular homeostasis implicated in the spectacular vascular collapse that is characteristic of anaphylaxis? And is the eNOS involved in anaphylaxis necessarily exerting its effect solely in the vascular endothelium, or might this "endothelial enzyme" actually be playing a more fundamental role in an entirely different tissue? After all, what's in a name?
UR - http://www.scopus.com/inward/record.url?scp=33746719376&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33746719376&partnerID=8YFLogxK
U2 - 10.1172/JCI29406
DO - 10.1172/JCI29406
M3 - Article
C2 - 16886052
AN - SCOPUS:33746719376
VL - 116
SP - 2075
EP - 2078
JO - Journal of Clinical Investigation
JF - Journal of Clinical Investigation
SN - 0021-9738
IS - 8
ER -