What's in a name? eNOS and anaphylactic shock

Charles J. Lowenstein, Thomas Michel

Research output: Contribution to journalArticle

Abstract

In this issue of the JCI, a study by Cauwels and colleagues suggests a central role for eNOS, the endothelial isoform of nitric oxide synthase, as a mediator of anaphylaxis (see the related article beginning on page 2244). Why is an enzyme originally described as a physiological mediator of vascular homeostasis implicated in the spectacular vascular collapse that is characteristic of anaphylaxis? And is the eNOS involved in anaphylaxis necessarily exerting its effect solely in the vascular endothelium, or might this "endothelial enzyme" actually be playing a more fundamental role in an entirely different tissue? After all, what's in a name?

Original languageEnglish (US)
Pages (from-to)2075-2078
Number of pages4
JournalJournal of Clinical Investigation
Volume116
Issue number8
DOIs
StatePublished - Aug 1 2006

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Anaphylaxis
Names
Blood Vessels
Nitric Oxide Synthase Type III
Vascular Endothelium
Enzymes
Protein Isoforms
Homeostasis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

What's in a name? eNOS and anaphylactic shock. / Lowenstein, Charles J.; Michel, Thomas.

In: Journal of Clinical Investigation, Vol. 116, No. 8, 01.08.2006, p. 2075-2078.

Research output: Contribution to journalArticle

Lowenstein, Charles J. ; Michel, Thomas. / What's in a name? eNOS and anaphylactic shock. In: Journal of Clinical Investigation. 2006 ; Vol. 116, No. 8. pp. 2075-2078.
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