What mechanisms underlie diastolic dysfunction in heart failure?

David A. Kass, Jean G.F. Bronzwaer, Walter J. Paulus

Research output: Contribution to journalReview articlepeer-review

365 Scopus citations


Abnormalities of diastolic function are common to virtually all forms of cardiac failure. However, their underlying mechanisms, precise role in the generation and phenotypic expression of heart failure, and value as specific therapeutic targets remain poorly understood. A growing proportion of heart failure patients, particularly among the elderly, have apparently preserved systolic function, and this is fueling interest for better understanding and treating diastolic abnormalities. Much of the attention in clinical and experimental studies has focused on relaxation and filling abnormalities of the heart, whereas chamber stiffness has been less well studied, particularly in humans. Nonetheless, new insights from basic and clinical research are helping define the regulators of diastolic dysfunction and illuminate novel targets for treatment. This review puts these developments into perspective with the major aim of highlighting current knowledge gaps and controversies.

Original languageEnglish (US)
Pages (from-to)1533-1542
Number of pages10
JournalCirculation research
Issue number12
StatePublished - Jun 25 2004


  • Compliance
  • Diastole
  • Dilated cardiomyopathy
  • Heart failure
  • Hypertrophy
  • Myocardium
  • Relaxation

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine


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