TY - JOUR
T1 - What is the optimal channel density for transmyocardial laser revascularization?
AU - Mouli, Samdeep K.
AU - Fronza, Jeffrey
AU - Greene, Rodney
AU - Robert, Emmanuel S.
AU - Horvath, Keith A.
N1 - Funding Information:
This research was supported by the National Institutes of Health 5R01HL064868–04.
PY - 2004/10
Y1 - 2004/10
N2 - Background Transmyocardial laser revascularization (TMR) has demonstrated reproducible relief of angina in patients with end-stage coronary disease. However, the optimum dose or channel density has not been elucidated. Methods Using a porcine model of chronic myocardial ischemia, 14 animals were treated with CO2 TMR and randomized as follows: group 1 was 1 channel per 2 cm2; group 2 was 1 channel per 1 cm2; and group 3 was 2 channels per 1 cm2. Left ventricular myocardial viability and function were assessed by magnetic resonance imaging (MRI) and echocardiography pretreatment, and repeated 6 weeks later. Results The MRI assessment of group 1 (1 channel/2 cm2) and group 2 (1 channel/cm2) demonstrated similar improvement in segmental contractility posttreatment of 12.11% ± 5.15% and 12.47% ± 9.51%, respectively. In contrast, group 3 (2 channels/cm2) showed significantly worse segmental contractility posttreatment: -18.52% ± 7.16% (p = 0.01). Echocardiographic imaging revealed significant improvements in wall thickening in the ischemic zone for group 1 at 0.91 ± 0.07 cm pretreatment versus 1.30 ± 0.09 cm posttreatment, (p = 0.01); and for group 2 at 0.93 ± 0.11 cm versus 1.42 ± 0.18 cm, (p = 0.01). No significant improvement in wall thickening was seen in group 3 (0.84 ± 0.06 cm versus 0.88 ± 0.09 cm, p = n.s.). Conclusions These data corroborate the empiric finding of an effective therapeutic dose range for TMR, 1 channel per 1 to 2 cm2. These results also demonstrate a detrimental effect when channel density is increased above the clinical standard of 1 channel per cm2 to a density of 2 channels per 1 cm2.
AB - Background Transmyocardial laser revascularization (TMR) has demonstrated reproducible relief of angina in patients with end-stage coronary disease. However, the optimum dose or channel density has not been elucidated. Methods Using a porcine model of chronic myocardial ischemia, 14 animals were treated with CO2 TMR and randomized as follows: group 1 was 1 channel per 2 cm2; group 2 was 1 channel per 1 cm2; and group 3 was 2 channels per 1 cm2. Left ventricular myocardial viability and function were assessed by magnetic resonance imaging (MRI) and echocardiography pretreatment, and repeated 6 weeks later. Results The MRI assessment of group 1 (1 channel/2 cm2) and group 2 (1 channel/cm2) demonstrated similar improvement in segmental contractility posttreatment of 12.11% ± 5.15% and 12.47% ± 9.51%, respectively. In contrast, group 3 (2 channels/cm2) showed significantly worse segmental contractility posttreatment: -18.52% ± 7.16% (p = 0.01). Echocardiographic imaging revealed significant improvements in wall thickening in the ischemic zone for group 1 at 0.91 ± 0.07 cm pretreatment versus 1.30 ± 0.09 cm posttreatment, (p = 0.01); and for group 2 at 0.93 ± 0.11 cm versus 1.42 ± 0.18 cm, (p = 0.01). No significant improvement in wall thickening was seen in group 3 (0.84 ± 0.06 cm versus 0.88 ± 0.09 cm, p = n.s.). Conclusions These data corroborate the empiric finding of an effective therapeutic dose range for TMR, 1 channel per 1 to 2 cm2. These results also demonstrate a detrimental effect when channel density is increased above the clinical standard of 1 channel per cm2 to a density of 2 channels per 1 cm2.
KW - 23
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U2 - 10.1016/j.athoracsur.2004.04.047
DO - 10.1016/j.athoracsur.2004.04.047
M3 - Article
C2 - 15464493
AN - SCOPUS:4644240175
SN - 0003-4975
VL - 78
SP - 1326
EP - 1331
JO - Annals of Thoracic Surgery
JF - Annals of Thoracic Surgery
IS - 4
ER -