Abstract
Background: Although the number of clinical trials assessing health related quality of life (HRQoL) in chronic heart failure (CHF) has increased exponentially over the last decade, little is known about the quality of reporting. The purpose of this review was to assess the methodological and reporting rigor of HRQoL in RCTs of pharmacological therapy in CHF. Methods: The electronic data bases, Medline and EMBASE were searched from 1990 to 2009 using the key search terms 'heart failure' combined with 'quality of life', 'pharmacological therapy' and 'randomized controlled trials'. A total of 136 articles were identified and evaluated according to the "Minimum Standard Checklist (MSC) for Evaluating HRQoL Outcomes". Results: According to the MSC criteria, 26 (19.1%) studies were considered 'very limited', 91 (66.9%) were 'limited' and only 19 (14.0%) studies were considered to be of a 'probably robust' in terms of methodological and reporting rigor. In fact, the quality of HRQoL reporting has not improved over time. Conclusion: HRQoL is a critical consideration in CHF management, yet reporting is highly variable. There is a need to develop a standardized method for measuring and reporting HRQoL measures in clinical trials to aid in the interpretation and application of findings.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 133-140 |
| Number of pages | 8 |
| Journal | International Journal of Cardiology |
| Volume | 164 |
| Issue number | 2 |
| DOIs | |
| State | Published - Apr 5 2013 |
| Externally published | Yes |
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Keywords
- Chronic heart failure
- Clinical decision making
- Health related quality of life
- Methodological quality
- Randomized clinical trials
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
What is the methodological and reporting quality of health related quality of life in chronic heart failure clinical trials? / Chang, Sungwon; Davidson, Patricia M; Newton, Phillip J.; Krum, Henry; Salamonson, Yenna; MacDonald, Peter.
In: International Journal of Cardiology, Vol. 164, No. 2, 05.04.2013, p. 133-140.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - What is the methodological and reporting quality of health related quality of life in chronic heart failure clinical trials?
AU - Chang, Sungwon
AU - Davidson, Patricia M
AU - Newton, Phillip J.
AU - Krum, Henry
AU - Salamonson, Yenna
AU - MacDonald, Peter
PY - 2013/4/5
Y1 - 2013/4/5
N2 - Background: Although the number of clinical trials assessing health related quality of life (HRQoL) in chronic heart failure (CHF) has increased exponentially over the last decade, little is known about the quality of reporting. The purpose of this review was to assess the methodological and reporting rigor of HRQoL in RCTs of pharmacological therapy in CHF. Methods: The electronic data bases, Medline and EMBASE were searched from 1990 to 2009 using the key search terms 'heart failure' combined with 'quality of life', 'pharmacological therapy' and 'randomized controlled trials'. A total of 136 articles were identified and evaluated according to the "Minimum Standard Checklist (MSC) for Evaluating HRQoL Outcomes". Results: According to the MSC criteria, 26 (19.1%) studies were considered 'very limited', 91 (66.9%) were 'limited' and only 19 (14.0%) studies were considered to be of a 'probably robust' in terms of methodological and reporting rigor. In fact, the quality of HRQoL reporting has not improved over time. Conclusion: HRQoL is a critical consideration in CHF management, yet reporting is highly variable. There is a need to develop a standardized method for measuring and reporting HRQoL measures in clinical trials to aid in the interpretation and application of findings.
AB - Background: Although the number of clinical trials assessing health related quality of life (HRQoL) in chronic heart failure (CHF) has increased exponentially over the last decade, little is known about the quality of reporting. The purpose of this review was to assess the methodological and reporting rigor of HRQoL in RCTs of pharmacological therapy in CHF. Methods: The electronic data bases, Medline and EMBASE were searched from 1990 to 2009 using the key search terms 'heart failure' combined with 'quality of life', 'pharmacological therapy' and 'randomized controlled trials'. A total of 136 articles were identified and evaluated according to the "Minimum Standard Checklist (MSC) for Evaluating HRQoL Outcomes". Results: According to the MSC criteria, 26 (19.1%) studies were considered 'very limited', 91 (66.9%) were 'limited' and only 19 (14.0%) studies were considered to be of a 'probably robust' in terms of methodological and reporting rigor. In fact, the quality of HRQoL reporting has not improved over time. Conclusion: HRQoL is a critical consideration in CHF management, yet reporting is highly variable. There is a need to develop a standardized method for measuring and reporting HRQoL measures in clinical trials to aid in the interpretation and application of findings.
KW - Chronic heart failure
KW - Clinical decision making
KW - Health related quality of life
KW - Methodological quality
KW - Randomized clinical trials
UR - http://www.scopus.com/inward/record.url?scp=84875219920&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84875219920&partnerID=8YFLogxK
U2 - 10.1016/j.ijcard.2012.01.019
DO - 10.1016/j.ijcard.2012.01.019
M3 - Article
C2 - 22310219
AN - SCOPUS:84875219920
VL - 164
SP - 133
EP - 140
JO - International Journal of Cardiology
JF - International Journal of Cardiology
SN - 0167-5273
IS - 2
ER -