What is the methodological and reporting quality of health related quality of life in chronic heart failure clinical trials?

Sungwon Chang, Patricia M Davidson, Phillip J. Newton, Henry Krum, Yenna Salamonson, Peter MacDonald

Research output: Contribution to journalArticle

Abstract

Background: Although the number of clinical trials assessing health related quality of life (HRQoL) in chronic heart failure (CHF) has increased exponentially over the last decade, little is known about the quality of reporting. The purpose of this review was to assess the methodological and reporting rigor of HRQoL in RCTs of pharmacological therapy in CHF. Methods: The electronic data bases, Medline and EMBASE were searched from 1990 to 2009 using the key search terms 'heart failure' combined with 'quality of life', 'pharmacological therapy' and 'randomized controlled trials'. A total of 136 articles were identified and evaluated according to the "Minimum Standard Checklist (MSC) for Evaluating HRQoL Outcomes". Results: According to the MSC criteria, 26 (19.1%) studies were considered 'very limited', 91 (66.9%) were 'limited' and only 19 (14.0%) studies were considered to be of a 'probably robust' in terms of methodological and reporting rigor. In fact, the quality of HRQoL reporting has not improved over time. Conclusion: HRQoL is a critical consideration in CHF management, yet reporting is highly variable. There is a need to develop a standardized method for measuring and reporting HRQoL measures in clinical trials to aid in the interpretation and application of findings.

Original languageEnglish (US)
Pages (from-to)133-140
Number of pages8
JournalInternational Journal of Cardiology
Volume164
Issue number2
DOIs
StatePublished - Apr 5 2013
Externally publishedYes

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Heart Failure
Quality of Life
Clinical Trials
Checklist
Pharmacology
Randomized Controlled Trials
Databases
Therapeutics

Keywords

  • Chronic heart failure
  • Clinical decision making
  • Health related quality of life
  • Methodological quality
  • Randomized clinical trials

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

What is the methodological and reporting quality of health related quality of life in chronic heart failure clinical trials? / Chang, Sungwon; Davidson, Patricia M; Newton, Phillip J.; Krum, Henry; Salamonson, Yenna; MacDonald, Peter.

In: International Journal of Cardiology, Vol. 164, No. 2, 05.04.2013, p. 133-140.

Research output: Contribution to journalArticle

Chang, Sungwon ; Davidson, Patricia M ; Newton, Phillip J. ; Krum, Henry ; Salamonson, Yenna ; MacDonald, Peter. / What is the methodological and reporting quality of health related quality of life in chronic heart failure clinical trials?. In: International Journal of Cardiology. 2013 ; Vol. 164, No. 2. pp. 133-140.
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