What is the effect of a mediterranean compared with a fast food meal on the exercise induced adipokine changes? A randomized cross-over clinical trial

Diana Silva, Rita Moreira, Marília Beltrão, Oksana Sokhatska, Tiago Montanha, Andreia Pizarro, Vanessa Garcia-Larsen    , Rodrigo Villegas, Luís Delgado, Pedro Moreira, Joana Carvalho, André Moreira

Research output: Contribution to journalArticle

Abstract

Background Adipose tissue-derived adipokines are pro-inflammatory cytokines involved in metabolic-related diseases and can be influenced by diet and exercise. We aimed to compare the effect of a Mediterranean (MdM) compared with Fast Food (FFM) meal on the exercise induced adipokines changes. Methods In a double blinded cross over trial, 46 participants were randomly assigned to one of two standardized iso-energy pre-exercise meals: FFM or MdM-type. Three hours after each meal, participants completed a treadmill exercise test (EC). Serum adiponectin, resistin, PAI-1, lipocalin-2/NGAL and adipsin were determined by Luminex magnetic bead immunoassay. Wilcoxon signed rank test compared changes before/after meal and before/after EC and a linear mixed model evaluated the effect of meals on the adipokine response to exercise, adjusted for confounders. Results Thirty-nine participants (mean age of 25, with a standard deviation of 5 years) completed the trial (56% females). For both interventions, a significant reduction of adipsin after each meal and a significant increase of lipocalin, PAI-1, adipsin and resistin, after exercise was observed. When exercise was preceded by a MdM meal a higher increase in adipsin levels was seen. Conclusion Acute exercise induced an increase of circulatory levels of adipsin, resistin, lipocalin and PAI-1, but not adiponectin. A pre-exercise Mediterranean meal potentiated the increase of adipsin after the exercise test, which possibly relates to the immune regulatory role of adipsin. These changes suggest a cross-talk between the immune and metabolic immediate response to exercise and its modulation by the pre-exercise diet composition.

Original languageEnglish (US)
Article numbere0215475
JournalPloS one
Volume14
Issue number4
DOIs
StatePublished - Apr 1 2019

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Complement Factor D
Fast Foods
adipokines
fast foods
Adipokines
Cross-Over Studies
Meals
clinical trials
exercise
Clinical Trials
Resistin
Exercise Test
Plasminogen Activator Inhibitor 1
resistin
Lipocalin 1
Lipocalins
exercise test
Adiponectin
Nutrition
adiponectin

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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What is the effect of a mediterranean compared with a fast food meal on the exercise induced adipokine changes? A randomized cross-over clinical trial. / Silva, Diana; Moreira, Rita; Beltrão, Marília; Sokhatska, Oksana; Montanha, Tiago; Pizarro, Andreia; Garcia-Larsen    , Vanessa; Villegas, Rodrigo; Delgado, Luís; Moreira, Pedro; Carvalho, Joana; Moreira, André.

In: PloS one, Vol. 14, No. 4, e0215475, 01.04.2019.

Research output: Contribution to journalArticle

Silva, D, Moreira, R, Beltrão, M, Sokhatska, O, Montanha, T, Pizarro, A, Garcia-Larsen    , V, Villegas, R, Delgado, L, Moreira, P, Carvalho, J & Moreira, A 2019, 'What is the effect of a mediterranean compared with a fast food meal on the exercise induced adipokine changes? A randomized cross-over clinical trial', PloS one, vol. 14, no. 4, e0215475. https://doi.org/10.1371/journal.pone.0215475
Silva, Diana ; Moreira, Rita ; Beltrão, Marília ; Sokhatska, Oksana ; Montanha, Tiago ; Pizarro, Andreia ; Garcia-Larsen    , Vanessa ; Villegas, Rodrigo ; Delgado, Luís ; Moreira, Pedro ; Carvalho, Joana ; Moreira, André. / What is the effect of a mediterranean compared with a fast food meal on the exercise induced adipokine changes? A randomized cross-over clinical trial. In: PloS one. 2019 ; Vol. 14, No. 4.
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abstract = "Background Adipose tissue-derived adipokines are pro-inflammatory cytokines involved in metabolic-related diseases and can be influenced by diet and exercise. We aimed to compare the effect of a Mediterranean (MdM) compared with Fast Food (FFM) meal on the exercise induced adipokines changes. Methods In a double blinded cross over trial, 46 participants were randomly assigned to one of two standardized iso-energy pre-exercise meals: FFM or MdM-type. Three hours after each meal, participants completed a treadmill exercise test (EC). Serum adiponectin, resistin, PAI-1, lipocalin-2/NGAL and adipsin were determined by Luminex magnetic bead immunoassay. Wilcoxon signed rank test compared changes before/after meal and before/after EC and a linear mixed model evaluated the effect of meals on the adipokine response to exercise, adjusted for confounders. Results Thirty-nine participants (mean age of 25, with a standard deviation of 5 years) completed the trial (56{\%} females). For both interventions, a significant reduction of adipsin after each meal and a significant increase of lipocalin, PAI-1, adipsin and resistin, after exercise was observed. When exercise was preceded by a MdM meal a higher increase in adipsin levels was seen. Conclusion Acute exercise induced an increase of circulatory levels of adipsin, resistin, lipocalin and PAI-1, but not adiponectin. A pre-exercise Mediterranean meal potentiated the increase of adipsin after the exercise test, which possibly relates to the immune regulatory role of adipsin. These changes suggest a cross-talk between the immune and metabolic immediate response to exercise and its modulation by the pre-exercise diet composition.",
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AU - Moreira, Rita

AU - Beltrão, Marília

AU - Sokhatska, Oksana

AU - Montanha, Tiago

AU - Pizarro, Andreia

AU - Garcia-Larsen    , Vanessa

AU - Villegas, Rodrigo

AU - Delgado, Luís

AU - Moreira, Pedro

AU - Carvalho, Joana

AU - Moreira, André

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N2 - Background Adipose tissue-derived adipokines are pro-inflammatory cytokines involved in metabolic-related diseases and can be influenced by diet and exercise. We aimed to compare the effect of a Mediterranean (MdM) compared with Fast Food (FFM) meal on the exercise induced adipokines changes. Methods In a double blinded cross over trial, 46 participants were randomly assigned to one of two standardized iso-energy pre-exercise meals: FFM or MdM-type. Three hours after each meal, participants completed a treadmill exercise test (EC). Serum adiponectin, resistin, PAI-1, lipocalin-2/NGAL and adipsin were determined by Luminex magnetic bead immunoassay. Wilcoxon signed rank test compared changes before/after meal and before/after EC and a linear mixed model evaluated the effect of meals on the adipokine response to exercise, adjusted for confounders. Results Thirty-nine participants (mean age of 25, with a standard deviation of 5 years) completed the trial (56% females). For both interventions, a significant reduction of adipsin after each meal and a significant increase of lipocalin, PAI-1, adipsin and resistin, after exercise was observed. When exercise was preceded by a MdM meal a higher increase in adipsin levels was seen. Conclusion Acute exercise induced an increase of circulatory levels of adipsin, resistin, lipocalin and PAI-1, but not adiponectin. A pre-exercise Mediterranean meal potentiated the increase of adipsin after the exercise test, which possibly relates to the immune regulatory role of adipsin. These changes suggest a cross-talk between the immune and metabolic immediate response to exercise and its modulation by the pre-exercise diet composition.

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