What is the effect of a mediterranean compared with a fast food meal on the exercise induced adipokine changes? A randomized cross-over clinical trial

Diana Silva, Rita Moreira, Marília Beltrão, Oksana Sokhatska, Tiago Montanha, Andreia Pizarro, Vanessa Garcia-Larsen, Rodrigo Villegas, Luís Delgado, Pedro Moreira, Joana Carvalho, André Moreira

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Abstract

Background Adipose tissue-derived adipokines are pro-inflammatory cytokines involved in metabolic-related diseases and can be influenced by diet and exercise. We aimed to compare the effect of a Mediterranean (MdM) compared with Fast Food (FFM) meal on the exercise induced adipokines changes. Methods In a double blinded cross over trial, 46 participants were randomly assigned to one of two standardized iso-energy pre-exercise meals: FFM or MdM-type. Three hours after each meal, participants completed a treadmill exercise test (EC). Serum adiponectin, resistin, PAI-1, lipocalin-2/NGAL and adipsin were determined by Luminex magnetic bead immunoassay. Wilcoxon signed rank test compared changes before/after meal and before/after EC and a linear mixed model evaluated the effect of meals on the adipokine response to exercise, adjusted for confounders. Results Thirty-nine participants (mean age of 25, with a standard deviation of 5 years) completed the trial (56% females). For both interventions, a significant reduction of adipsin after each meal and a significant increase of lipocalin, PAI-1, adipsin and resistin, after exercise was observed. When exercise was preceded by a MdM meal a higher increase in adipsin levels was seen. Conclusion Acute exercise induced an increase of circulatory levels of adipsin, resistin, lipocalin and PAI-1, but not adiponectin. A pre-exercise Mediterranean meal potentiated the increase of adipsin after the exercise test, which possibly relates to the immune regulatory role of adipsin. These changes suggest a cross-talk between the immune and metabolic immediate response to exercise and its modulation by the pre-exercise diet composition.

Original languageEnglish (US)
Article numbere0215475
JournalPloS one
Volume14
Issue number4
DOIs
StatePublished - Apr 2019

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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    Silva, D., Moreira, R., Beltrão, M., Sokhatska, O., Montanha, T., Pizarro, A., Garcia-Larsen, V., Villegas, R., Delgado, L., Moreira, P., Carvalho, J., & Moreira, A. (2019). What is the effect of a mediterranean compared with a fast food meal on the exercise induced adipokine changes? A randomized cross-over clinical trial. PloS one, 14(4), [e0215475]. https://doi.org/10.1371/journal.pone.0215475