TY - JOUR
T1 - What dopamine does in the brain
AU - Snyder, Solomon H.
PY - 2011/11/22
Y1 - 2011/11/22
N2 - In the early 1970s, receptors for neurotransmitters acting via second messengers had not been identified biochemically nor were there definitive links to such messengers. The discovery by John W. Kebabian and Paul Greengard of a dopamine-sensitive adenyl cyclase, accordingly, was a giant step forward. The investigators first characterized the enzyme in sympathetic ganglia wherein dopamineproducing cells link pre- and post-synaptic neurons. Then, in the corpus striatum, the brain area enriched in dopamine, they delineated the enzyme's properties and showed that it was inhibited by antipsychotic drugs, leading to a large body of research on dopamine as amediator of antipsychotic drug action and putative roles for this transmitter in the pathophysiology of schizophrenia.
AB - In the early 1970s, receptors for neurotransmitters acting via second messengers had not been identified biochemically nor were there definitive links to such messengers. The discovery by John W. Kebabian and Paul Greengard of a dopamine-sensitive adenyl cyclase, accordingly, was a giant step forward. The investigators first characterized the enzyme in sympathetic ganglia wherein dopamineproducing cells link pre- and post-synaptic neurons. Then, in the corpus striatum, the brain area enriched in dopamine, they delineated the enzyme's properties and showed that it was inhibited by antipsychotic drugs, leading to a large body of research on dopamine as amediator of antipsychotic drug action and putative roles for this transmitter in the pathophysiology of schizophrenia.
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U2 - 10.1073/pnas.1114346108
DO - 10.1073/pnas.1114346108
M3 - Short survey
C2 - 22106252
AN - SCOPUS:82755168828
SN - 0027-8424
VL - 108
SP - 18869
EP - 18871
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 47
ER -