What causes cell death in Parkinson's disease?

Amitabh Gupta, Valina Dawson, Ted M Dawson

Research output: Contribution to journalArticle

Abstract

Currently, there is no proven neuroprotective or neurorestorative therapy for Parkinson's disease (PD). Several advances in the genetics of PD have created an opportunity to develop mechanistic-based therapies that hold particular promise for identifying agents that slow and even halt the progression of PD, as well as restore function. Here we review many of the advances in the last decade regarding the identification of new targets for the treatment of PD based on understanding the molecular mechanisms of how mutations in genes linked to PD cause neurodegeneration.

Original languageEnglish (US)
JournalAnnals of Neurology
Volume64
Issue numberSUPPL. 2
DOIs
StatePublished - Dec 2008

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Parkinson Disease
Cause of Death
Cell Death
Inborn Genetic Diseases
Mutation
Therapeutics
Genes

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

What causes cell death in Parkinson's disease? / Gupta, Amitabh; Dawson, Valina; Dawson, Ted M.

In: Annals of Neurology, Vol. 64, No. SUPPL. 2, 12.2008.

Research output: Contribution to journalArticle

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