What causes cell death in Parkinson's disease?

Research output: Contribution to journalReview articlepeer-review


Currently, there is no proven neuroprotective or neurorestorative therapy for Parkinson's disease (PD). Several advances in the genetics of PD have created an opportunity to develop mechanistic-based therapies that hold particular promise for identifying agents that slow and even halt the progression of PD, as well as restore function. Here we review many of the advances in the last decade regarding the identification of new targets for the treatment of PD based on understanding the molecular mechanisms of how mutations in genes linked to PD cause neurodegeneration.

Original languageEnglish (US)
Pages (from-to)S3-S15
JournalAnnals of neurology
Issue numberSUPPL. 2
StatePublished - Dec 2008

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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