What are the threats to successful brain and cognitive aging?

Michela Gallagher, Ozioma C. Okonkwo, Susan M. Resnick, William J. Jagust, Tammie L.S. Benzinger, Peter R. Rapp

Research output: Contribution to journalArticle

Abstract

The structure and function of the brain change over the life span. Aged brains often accumulate pathologic lesions, such as amyloid plaques and tau tangles, which lead to diminished cognitive ability in some, but not all, individuals. The basis of this vulnerability and resilience is unclear. Age-related changes can alter neural firing patterns and ability to form new memories. Risk factors for cognitive decline include male sex and apolipoprotein E genotype. Physical activity seems to be protective against cognitive decline. Longitudinal studies have shown that, although the onset of amyloid pathology and associated cognitive decline can vary greatly, once it begins, the rate of deposition is similar among affected individuals. This session of the Cognitive Aging Summit III explored fixed and modifiable factors that can threaten cognitive function in aging adults and approaches to modulate at least some of these risks.

Original languageEnglish (US)
JournalNeurobiology of Aging
DOIs
StatePublished - Jan 1 2019

Fingerprint

Aptitude
Brain
Amyloid Plaques
Apolipoproteins E
Amyloid
Cognition
Longitudinal Studies
Genotype
Pathology
Cognitive Dysfunction
Cognitive Aging

Keywords

  • Compensation
  • Maintenance
  • Modifiable factors
  • Pathology
  • Reserve
  • Resilience

ASJC Scopus subject areas

  • Neuroscience(all)
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

Cite this

What are the threats to successful brain and cognitive aging? / Gallagher, Michela; Okonkwo, Ozioma C.; Resnick, Susan M.; Jagust, William J.; Benzinger, Tammie L.S.; Rapp, Peter R.

In: Neurobiology of Aging, 01.01.2019.

Research output: Contribution to journalArticle

Gallagher, Michela ; Okonkwo, Ozioma C. ; Resnick, Susan M. ; Jagust, William J. ; Benzinger, Tammie L.S. ; Rapp, Peter R. / What are the threats to successful brain and cognitive aging?. In: Neurobiology of Aging. 2019.
@article{2e6cf8a1c2944cffb879d65eed8bae85,
title = "What are the threats to successful brain and cognitive aging?",
abstract = "The structure and function of the brain change over the life span. Aged brains often accumulate pathologic lesions, such as amyloid plaques and tau tangles, which lead to diminished cognitive ability in some, but not all, individuals. The basis of this vulnerability and resilience is unclear. Age-related changes can alter neural firing patterns and ability to form new memories. Risk factors for cognitive decline include male sex and apolipoprotein E genotype. Physical activity seems to be protective against cognitive decline. Longitudinal studies have shown that, although the onset of amyloid pathology and associated cognitive decline can vary greatly, once it begins, the rate of deposition is similar among affected individuals. This session of the Cognitive Aging Summit III explored fixed and modifiable factors that can threaten cognitive function in aging adults and approaches to modulate at least some of these risks.",
keywords = "Compensation, Maintenance, Modifiable factors, Pathology, Reserve, Resilience",
author = "Michela Gallagher and Okonkwo, {Ozioma C.} and Resnick, {Susan M.} and Jagust, {William J.} and Benzinger, {Tammie L.S.} and Rapp, {Peter R.}",
year = "2019",
month = "1",
day = "1",
doi = "10.1016/j.neurobiolaging.2019.04.016",
language = "English (US)",
journal = "Neurobiology of Aging",
issn = "0197-4580",
publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - What are the threats to successful brain and cognitive aging?

AU - Gallagher, Michela

AU - Okonkwo, Ozioma C.

AU - Resnick, Susan M.

AU - Jagust, William J.

AU - Benzinger, Tammie L.S.

AU - Rapp, Peter R.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - The structure and function of the brain change over the life span. Aged brains often accumulate pathologic lesions, such as amyloid plaques and tau tangles, which lead to diminished cognitive ability in some, but not all, individuals. The basis of this vulnerability and resilience is unclear. Age-related changes can alter neural firing patterns and ability to form new memories. Risk factors for cognitive decline include male sex and apolipoprotein E genotype. Physical activity seems to be protective against cognitive decline. Longitudinal studies have shown that, although the onset of amyloid pathology and associated cognitive decline can vary greatly, once it begins, the rate of deposition is similar among affected individuals. This session of the Cognitive Aging Summit III explored fixed and modifiable factors that can threaten cognitive function in aging adults and approaches to modulate at least some of these risks.

AB - The structure and function of the brain change over the life span. Aged brains often accumulate pathologic lesions, such as amyloid plaques and tau tangles, which lead to diminished cognitive ability in some, but not all, individuals. The basis of this vulnerability and resilience is unclear. Age-related changes can alter neural firing patterns and ability to form new memories. Risk factors for cognitive decline include male sex and apolipoprotein E genotype. Physical activity seems to be protective against cognitive decline. Longitudinal studies have shown that, although the onset of amyloid pathology and associated cognitive decline can vary greatly, once it begins, the rate of deposition is similar among affected individuals. This session of the Cognitive Aging Summit III explored fixed and modifiable factors that can threaten cognitive function in aging adults and approaches to modulate at least some of these risks.

KW - Compensation

KW - Maintenance

KW - Modifiable factors

KW - Pathology

KW - Reserve

KW - Resilience

UR - http://www.scopus.com/inward/record.url?scp=85067994094&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85067994094&partnerID=8YFLogxK

U2 - 10.1016/j.neurobiolaging.2019.04.016

DO - 10.1016/j.neurobiolaging.2019.04.016

M3 - Article

C2 - 31732016

JO - Neurobiology of Aging

JF - Neurobiology of Aging

SN - 0197-4580

ER -