What are the psychiatric manifestations of vitamin B12 deficiency?

John R Burton, J. R. Burton

Research output: Contribution to journalArticle

Abstract

Psychiatric symptoms attributable to vitamin B12 deficiency have been described for decades. The earlier reports are for the most part in accord with more recent ones, despite being diagnostically less specific in psychiatric and hematologic terms. These symptoms seem to fall into several clinically separate categories: slow cerebration; confusion; memory changes; delirium, with or without hallucinations and/or delusions; depression; acute psychotic states; and (more rarely) reversible manic and schizophreniform states. While there still remain abundant hematologic, psychiatric, neurologic, or nutritional reasons for obtaining a serum vitamin B12 level, its use in the investigation of the etiology of a patient's dementia seems unjustified. However, acute or subacute changes in a demented patient's mental status, specifically a clouding of their consciousness, may make such testing advisable as part of the complete workup of their delirium regardless of a normal hematologic picture.

Original languageEnglish (US)
Pages (from-to)1105-1112
Number of pages8
JournalJournal of the American Geriatrics Society
Volume36
Issue number12
StatePublished - 1988

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Vitamin B 12 Deficiency
Psychiatry
Delirium
Confusion
Delusions
Hallucinations
Mentally Ill Persons
Vitamin B 12
Consciousness
Bipolar Disorder
Nervous System
Dementia
Depression
Serum

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

What are the psychiatric manifestations of vitamin B12 deficiency? / Burton, John R; Burton, J. R.

In: Journal of the American Geriatrics Society, Vol. 36, No. 12, 1988, p. 1105-1112.

Research output: Contribution to journalArticle

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