TY - JOUR
T1 - Well-differentiated villoglandular adenocarcinoma of the uterine cervix
T2 - A clinicopathological study of 24 cases
AU - Jones, Mirka W.
AU - Silverberg, Steven G.
AU - Kurman, Robert J.
PY - 1993/1
Y1 - 1993/1
N2 - We reviewed the clinical and pathological features of 24 cases of well-differentiated villoglandular adenocarcinoma of the uterine cervix. The patient’s ages ranged from 27 to 54 years, with an average age of 37. At least 15 patients were taking oral contraceptives prior to diagnosis, compared to five of 18 in a control group of patients with various other histologic types of cervical adenocarcinoma. All of the neoplasms were exophytic polypoid lesions with thick or thin papillae lined by endocervical, endometrial or intestinal-type epithelium showing mild cytologic atypia. Ten were associated with adenocarcinoma in situ, eight with cervical intraepithelial neoplasia, and one with microglandular hyperplasia. All tumors were confined to the cervix. Five patients were treated by excisional biopsy or cone biopsy, four by simple hysterectomy with prior or subsequent radiation therapy, and 15 by radical hysterectomy. All patients are alive and well, with no evidence of recurrent disease. The follow-up ranged from 7 to 77 months, with a mean of 36 months.
AB - We reviewed the clinical and pathological features of 24 cases of well-differentiated villoglandular adenocarcinoma of the uterine cervix. The patient’s ages ranged from 27 to 54 years, with an average age of 37. At least 15 patients were taking oral contraceptives prior to diagnosis, compared to five of 18 in a control group of patients with various other histologic types of cervical adenocarcinoma. All of the neoplasms were exophytic polypoid lesions with thick or thin papillae lined by endocervical, endometrial or intestinal-type epithelium showing mild cytologic atypia. Ten were associated with adenocarcinoma in situ, eight with cervical intraepithelial neoplasia, and one with microglandular hyperplasia. All tumors were confined to the cervix. Five patients were treated by excisional biopsy or cone biopsy, four by simple hysterectomy with prior or subsequent radiation therapy, and 15 by radical hysterectomy. All patients are alive and well, with no evidence of recurrent disease. The follow-up ranged from 7 to 77 months, with a mean of 36 months.
KW - Oral contraceptives
KW - Uterine cervix
KW - Well-differentiated villoglandular adenocarcinoma
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U2 - 10.1097/00004347-199301000-00001
DO - 10.1097/00004347-199301000-00001
M3 - Article
C2 - 8418074
AN - SCOPUS:0027469010
SN - 0277-1691
VL - 12
SP - 1
EP - 7
JO - International Journal of Gynecological Pathology
JF - International Journal of Gynecological Pathology
IS - 1
ER -