Weight loss interventions in asthma: EAACI evidence-based clinical practice guideline (Part I)

A. Moreira, M. Bonini, Vanessa Garcia-Larsen    , S. Bonini, S. R. Del Giacco, I. Agache, J. Fonseca, N. G. Papadopoulos, K. H. Carlsen, L. Delgado, T. Haahtela

Research output: Contribution to journalArticle

Abstract

Background: Asthma and obesity are chronic multifactorial conditions that are associated with gene-environment interaction and immune function. Although the data are not fully consistent, it seems that obesity increases the risk of asthma and compromises asthma control. Objective To investigate the impact that weight changes have on asthma. Methods: We carried out a systematic review of three large biomedical databases. Studies were scrutinized and critically appraised according to agreed exclusion and inclusion criteria. Quality assessment of eligible papers was conducted using the GRADE method. Meta-analyses of comparable studies were carried out. Results: Thirty studies met the eligibility criteria of the review. Interventions were limited to dietary manipulation in three studies, one of which also used anti-obesity drugs, and bariatric surgery in four. All the other studies reported observational data. Becoming obese increased the odds for incident asthma by 1.82 (95% CI 1.47, 2.25) in adults and 1.98 (95% CI 0.71, 5.52) in children. Weight loss was associated with significant improvement in mean scores for symptoms, rescue medication score, and asthma exacerbations in the only randomized controlled trial. Similarly, evidence gathered from observational studies, with follow-up ranging between 8 weeks to 1 year, and from changes 1 year after bariatric surgery showed improvements in all asthma control-related outcomes. Changes in lung function were reported in one randomized controlled and eight observational studies of asthmatic subjects, with conflicting results. Either improvement after weight loss, decline with weight gain, or no effects at all were reported. Changes in airway inflammation and responsiveness were reported only by observational studies. Conclusion Weight increases above the obesity threshold significantly increase the risk of asthma. The available studies show weak evidence of benefits from weight reduction on asthma outcomes.

Original languageEnglish (US)
Pages (from-to)425-439
Number of pages15
JournalAllergy: European Journal of Allergy and Clinical Immunology
Volume68
Issue number4
DOIs
StatePublished - Apr 2013
Externally publishedYes

Fingerprint

Evidence-Based Practice
Practice Guidelines
Weight Loss
Asthma
Observational Studies
Bariatric Surgery
Obesity
Anti-Obesity Agents
Weights and Measures
Gene-Environment Interaction
Weight Gain
Meta-Analysis
Randomized Controlled Trials
Databases
Inflammation
Lung

Keywords

  • asthma
  • meta-analysis
  • obesity
  • systematic review
  • weight change

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Weight loss interventions in asthma : EAACI evidence-based clinical practice guideline (Part I). / Moreira, A.; Bonini, M.; Garcia-Larsen    , Vanessa; Bonini, S.; Del Giacco, S. R.; Agache, I.; Fonseca, J.; Papadopoulos, N. G.; Carlsen, K. H.; Delgado, L.; Haahtela, T.

In: Allergy: European Journal of Allergy and Clinical Immunology, Vol. 68, No. 4, 04.2013, p. 425-439.

Research output: Contribution to journalArticle

Moreira, A, Bonini, M, Garcia-Larsen    , V, Bonini, S, Del Giacco, SR, Agache, I, Fonseca, J, Papadopoulos, NG, Carlsen, KH, Delgado, L & Haahtela, T 2013, 'Weight loss interventions in asthma: EAACI evidence-based clinical practice guideline (Part I)', Allergy: European Journal of Allergy and Clinical Immunology, vol. 68, no. 4, pp. 425-439. https://doi.org/10.1111/all.12106
Moreira, A. ; Bonini, M. ; Garcia-Larsen    , Vanessa ; Bonini, S. ; Del Giacco, S. R. ; Agache, I. ; Fonseca, J. ; Papadopoulos, N. G. ; Carlsen, K. H. ; Delgado, L. ; Haahtela, T. / Weight loss interventions in asthma : EAACI evidence-based clinical practice guideline (Part I). In: Allergy: European Journal of Allergy and Clinical Immunology. 2013 ; Vol. 68, No. 4. pp. 425-439.
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abstract = "Background: Asthma and obesity are chronic multifactorial conditions that are associated with gene-environment interaction and immune function. Although the data are not fully consistent, it seems that obesity increases the risk of asthma and compromises asthma control. Objective To investigate the impact that weight changes have on asthma. Methods: We carried out a systematic review of three large biomedical databases. Studies were scrutinized and critically appraised according to agreed exclusion and inclusion criteria. Quality assessment of eligible papers was conducted using the GRADE method. Meta-analyses of comparable studies were carried out. Results: Thirty studies met the eligibility criteria of the review. Interventions were limited to dietary manipulation in three studies, one of which also used anti-obesity drugs, and bariatric surgery in four. All the other studies reported observational data. Becoming obese increased the odds for incident asthma by 1.82 (95{\%} CI 1.47, 2.25) in adults and 1.98 (95{\%} CI 0.71, 5.52) in children. Weight loss was associated with significant improvement in mean scores for symptoms, rescue medication score, and asthma exacerbations in the only randomized controlled trial. Similarly, evidence gathered from observational studies, with follow-up ranging between 8 weeks to 1 year, and from changes 1 year after bariatric surgery showed improvements in all asthma control-related outcomes. Changes in lung function were reported in one randomized controlled and eight observational studies of asthmatic subjects, with conflicting results. Either improvement after weight loss, decline with weight gain, or no effects at all were reported. Changes in airway inflammation and responsiveness were reported only by observational studies. Conclusion Weight increases above the obesity threshold significantly increase the risk of asthma. The available studies show weak evidence of benefits from weight reduction on asthma outcomes.",
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AU - Bonini, M.

AU - Garcia-Larsen    , Vanessa

AU - Bonini, S.

AU - Del Giacco, S. R.

AU - Agache, I.

AU - Fonseca, J.

AU - Papadopoulos, N. G.

AU - Carlsen, K. H.

AU - Delgado, L.

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N2 - Background: Asthma and obesity are chronic multifactorial conditions that are associated with gene-environment interaction and immune function. Although the data are not fully consistent, it seems that obesity increases the risk of asthma and compromises asthma control. Objective To investigate the impact that weight changes have on asthma. Methods: We carried out a systematic review of three large biomedical databases. Studies were scrutinized and critically appraised according to agreed exclusion and inclusion criteria. Quality assessment of eligible papers was conducted using the GRADE method. Meta-analyses of comparable studies were carried out. Results: Thirty studies met the eligibility criteria of the review. Interventions were limited to dietary manipulation in three studies, one of which also used anti-obesity drugs, and bariatric surgery in four. All the other studies reported observational data. Becoming obese increased the odds for incident asthma by 1.82 (95% CI 1.47, 2.25) in adults and 1.98 (95% CI 0.71, 5.52) in children. Weight loss was associated with significant improvement in mean scores for symptoms, rescue medication score, and asthma exacerbations in the only randomized controlled trial. Similarly, evidence gathered from observational studies, with follow-up ranging between 8 weeks to 1 year, and from changes 1 year after bariatric surgery showed improvements in all asthma control-related outcomes. Changes in lung function were reported in one randomized controlled and eight observational studies of asthmatic subjects, with conflicting results. Either improvement after weight loss, decline with weight gain, or no effects at all were reported. Changes in airway inflammation and responsiveness were reported only by observational studies. Conclusion Weight increases above the obesity threshold significantly increase the risk of asthma. The available studies show weak evidence of benefits from weight reduction on asthma outcomes.

AB - Background: Asthma and obesity are chronic multifactorial conditions that are associated with gene-environment interaction and immune function. Although the data are not fully consistent, it seems that obesity increases the risk of asthma and compromises asthma control. Objective To investigate the impact that weight changes have on asthma. Methods: We carried out a systematic review of three large biomedical databases. Studies were scrutinized and critically appraised according to agreed exclusion and inclusion criteria. Quality assessment of eligible papers was conducted using the GRADE method. Meta-analyses of comparable studies were carried out. Results: Thirty studies met the eligibility criteria of the review. Interventions were limited to dietary manipulation in three studies, one of which also used anti-obesity drugs, and bariatric surgery in four. All the other studies reported observational data. Becoming obese increased the odds for incident asthma by 1.82 (95% CI 1.47, 2.25) in adults and 1.98 (95% CI 0.71, 5.52) in children. Weight loss was associated with significant improvement in mean scores for symptoms, rescue medication score, and asthma exacerbations in the only randomized controlled trial. Similarly, evidence gathered from observational studies, with follow-up ranging between 8 weeks to 1 year, and from changes 1 year after bariatric surgery showed improvements in all asthma control-related outcomes. Changes in lung function were reported in one randomized controlled and eight observational studies of asthmatic subjects, with conflicting results. Either improvement after weight loss, decline with weight gain, or no effects at all were reported. Changes in airway inflammation and responsiveness were reported only by observational studies. Conclusion Weight increases above the obesity threshold significantly increase the risk of asthma. The available studies show weak evidence of benefits from weight reduction on asthma outcomes.

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