TY - JOUR
T1 - Weight Loss During the Intensive Intervention Phase of the Weight-Loss Maintenance Trial
AU - Hollis, Jack F.
AU - Gullion, Christina M.
AU - Stevens, Victor J.
AU - Brantley, Phillip J.
AU - Appel, Lawrence J.
AU - Ard, Jamy D.
AU - Champagne, Catherine M.
AU - Dalcin, Arlene
AU - Erlinger, Thomas P.
AU - Funk, Kristine
AU - Laferriere, Daniel
AU - Lin, Pao Hwa
AU - Loria, Catherine M.
AU - Samuel-Hodge, Carmen
AU - Vollmer, William M.
AU - Svetkey, Laura P.
N1 - Funding Information:
The WLM trial was an investigator-initiated trial sponsored by the National Heart, Lung, and Blood Institute (NHLBI). It was reviewed and approved by IRBs at the participating institutions and by an NHLBI-appointed protocol review committee. NHLBI collaborated in the design and oversight of the trial, the analysis and interpretation of the data, and reviewed this manuscript. All participants provided written informed consent.
Funding Information:
This work was supported by National Heart, Lung, Blood Institute grants 5-U01 HL68920, 5-U01 HL68734, 5-U01 HL68676, 5-U01 HL68790 and 5-HL68955. We also wish to thank the WLM Data and Safety Monitoring Board and special thanks go to the WLM participants that made this study possible.
PY - 2008/8
Y1 - 2008/8
N2 - Background: To improve methods for long-term weight management, the Weight Loss Maintenance (WLM) trial, a four-center randomized trial, was conducted to compare alternative strategies for maintaining weight loss over a 30-month period. This paper describes methods and results for the initial 6-month weight-loss program (Phase I). Methods: Eligible adults were aged ≥25, overweight or obese (BMI=25-45 kg/m2), and on medications for hypertension and/or dyslipidemia. Anthropomorphic, demographic, and psychosocial measures were collected at baseline and 6 months. Participants (n=1685) attended 20 weekly group sessions to encourage calorie restriction, moderate-intensity physical activity, and the DASH (dietary approaches to stop hypertension) dietary pattern. Weight-loss predictors with missing data were replaced by multiple imputation. Results: Participants were 44% African American and 67% women; 79% were obese (BMI≥30), 87% were taking anti-hypertensive medications, and 38% were taking antidyslipidemia medications. Participants attended an average of 72% of 20 group sessions. They self-reported 117 minutes of moderate-intensity physical activity per week, kept 3.7 daily food records per week, and consumed 2.9 servings of fruits and vegetables per day. The Phase-I follow-up rate was 92%. Mean (SD) weight change was -5.8 kg (4.4), and 69% lost at least 4 kg. All race-gender subgroups lost substantial weight: African-American men (-5.4 kg ± 7.7); African-American women (-4.1 kg ± 2.9); non-African-American men (-8.5 kg ± 12.9); and non-African-American women (-5.8 kg ± 6.1). Behavioral measures (e.g., diet records and physical activity) accounted for most of the weight-loss variation, although the association between behavioral measures and weight loss differed by race and gender groups. Conclusions: The WLM behavioral intervention successfully achieved clinically significant short-term weight loss in a diverse population of high-risk patients.
AB - Background: To improve methods for long-term weight management, the Weight Loss Maintenance (WLM) trial, a four-center randomized trial, was conducted to compare alternative strategies for maintaining weight loss over a 30-month period. This paper describes methods and results for the initial 6-month weight-loss program (Phase I). Methods: Eligible adults were aged ≥25, overweight or obese (BMI=25-45 kg/m2), and on medications for hypertension and/or dyslipidemia. Anthropomorphic, demographic, and psychosocial measures were collected at baseline and 6 months. Participants (n=1685) attended 20 weekly group sessions to encourage calorie restriction, moderate-intensity physical activity, and the DASH (dietary approaches to stop hypertension) dietary pattern. Weight-loss predictors with missing data were replaced by multiple imputation. Results: Participants were 44% African American and 67% women; 79% were obese (BMI≥30), 87% were taking anti-hypertensive medications, and 38% were taking antidyslipidemia medications. Participants attended an average of 72% of 20 group sessions. They self-reported 117 minutes of moderate-intensity physical activity per week, kept 3.7 daily food records per week, and consumed 2.9 servings of fruits and vegetables per day. The Phase-I follow-up rate was 92%. Mean (SD) weight change was -5.8 kg (4.4), and 69% lost at least 4 kg. All race-gender subgroups lost substantial weight: African-American men (-5.4 kg ± 7.7); African-American women (-4.1 kg ± 2.9); non-African-American men (-8.5 kg ± 12.9); and non-African-American women (-5.8 kg ± 6.1). Behavioral measures (e.g., diet records and physical activity) accounted for most of the weight-loss variation, although the association between behavioral measures and weight loss differed by race and gender groups. Conclusions: The WLM behavioral intervention successfully achieved clinically significant short-term weight loss in a diverse population of high-risk patients.
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U2 - 10.1016/j.amepre.2008.04.013
DO - 10.1016/j.amepre.2008.04.013
M3 - Article
C2 - 18617080
AN - SCOPUS:46449089693
SN - 0749-3797
VL - 35
SP - 118
EP - 126
JO - American journal of preventive medicine
JF - American journal of preventive medicine
IS - 2
ER -