TY - JOUR
T1 - Wegener's granulomatosis
T2 - Managing more than inflammation
AU - Seo, Philip
PY - 2008/1
Y1 - 2008/1
N2 - PURPOSE OF REVIEW: Although studies of Wegener's granulomatosis frequently focus on controlling disease activity, the prevention of the chronic morbidity - known as damage - may be equally important. The first part of this review explores the concept of damage and its relevance to the diagnosis of Wegener's granulomatosis. The second part focuses on specific forms of damage associated with Wegener's granulomatosis. RECENT FINDINGS: Some forms of damage (such as subglottic stenosis or renal insufficiency) occur as the direct result of the disease; other forms (such as osteoporosis or gonadal failure) are the result of the drugs used to treat it. There is an ongoing international effort to revise the way in which damage is measured; this initiative will benefit from longitudinal studies of vasculitis that are being conducted in the US and in Europe. Despite advances in therapeutics, renal damage in particular continues to be an important source of morbidity among patients with Wegener's granulomatosis. Recent years have also revealed previously unexpected associations between Wegener's granulomatosis and the incidence of malignancy, venous thromboembolic events, and cardiovascular disease. SUMMARY: Damage remains an important concern for all patients with Wegener's granulomatosis. Future studies of this disease must focus on both the early identification and prevention of damage.
AB - PURPOSE OF REVIEW: Although studies of Wegener's granulomatosis frequently focus on controlling disease activity, the prevention of the chronic morbidity - known as damage - may be equally important. The first part of this review explores the concept of damage and its relevance to the diagnosis of Wegener's granulomatosis. The second part focuses on specific forms of damage associated with Wegener's granulomatosis. RECENT FINDINGS: Some forms of damage (such as subglottic stenosis or renal insufficiency) occur as the direct result of the disease; other forms (such as osteoporosis or gonadal failure) are the result of the drugs used to treat it. There is an ongoing international effort to revise the way in which damage is measured; this initiative will benefit from longitudinal studies of vasculitis that are being conducted in the US and in Europe. Despite advances in therapeutics, renal damage in particular continues to be an important source of morbidity among patients with Wegener's granulomatosis. Recent years have also revealed previously unexpected associations between Wegener's granulomatosis and the incidence of malignancy, venous thromboembolic events, and cardiovascular disease. SUMMARY: Damage remains an important concern for all patients with Wegener's granulomatosis. Future studies of this disease must focus on both the early identification and prevention of damage.
KW - Damage
KW - Vasculitis damage index
KW - Wegener's granulomatosis
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U2 - 10.1097/BOR.0b013e3282f18bef
DO - 10.1097/BOR.0b013e3282f18bef
M3 - Review article
C2 - 18281851
AN - SCOPUS:40349113154
VL - 20
SP - 10
EP - 16
JO - Current Opinion in Rheumatology
JF - Current Opinion in Rheumatology
SN - 1040-8711
IS - 1
ER -