Web-based application to project the burden of Alzheimer's disease

Elizabeth Colantuoni, Greg Surplus, Andre Hackman, H. Michael Arrighi, Ron Brookmeyer

Research output: Contribution to journalArticlepeer-review


Background: Health care planning and research would benefit from tools that enable researchers to project the future burden of Alzheimer's disease (AD) and evaluate the effect of potential interventions. Methods: We created a web-based application of the AD prevalence model developed by Brookmeyer et al (Am J Public Health 1998;88:1337-42; Alzheimers Dement 2007;3:186-91). The user defines the disease parameters and any interventions that may either reduce risk or slow disease progression. We expanded the parameters to include the cost and weights for disability-adjusted life years. Application: The secure, web-based application generates detailed AD projections for each calendar year to 2050, and allows users to create personal accounts for them to save, retrieve, and modify the input parameters. The flexibility of the application is illustrated with a forecast for the state of Maryland, USA. Conclusions: The application generates AD burden projections, costs, and disability-adjusted life years, along with changes associated with potential interventions.

Original languageEnglish (US)
Pages (from-to)425-428
Number of pages4
JournalAlzheimer's and Dementia
Issue number5
StatePublished - Sep 2010


  • Costs
  • Disability-adjusted life years (DALYs)
  • Disease burden
  • Forecasting
  • Multi-stage disease model
  • Preventative therapy
  • Web-tool

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Clinical Neurology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience


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