Wearable potentiometric chloride sweat sensor: The critical role of the salt bridge

Dong Hoon Choi, Jin Seob Kim, Garry R Cutting, Peter C. Searson

Research output: Contribution to journalArticle

Abstract

The components of sweat provide an array of potential biomarkers for health and disease. Sweat chloride is of interest as a biomarker for cystic fibrosis, electrolyte metabolism disorders, electrolyte balance, and electrolyte loss during exercise. Developing wearable sensors for biomarkers in sweat is a major technological challenge. Potentiometric sensors provide a relatively simple technology for on-body sweat chloride measurement however equilibration between reference and test solutions has limited the time over which accurate measurements can be made. Here, we report on a wearable potentiometric chloride sweat sensor. We performed parametric studies to show how the salt bridge geometry determines equilibration between the reference and test solutions. From these results, we show a sweat chloride sensor can be designed to provide accurate measurements over extended times. We then performed on-body tests on healthy subjects while exercising to establish the feasibility of using this technology as a wearable device.

Original languageEnglish (US)
Pages (from-to)12241-12247
Number of pages7
JournalAnalytical Chemistry
Volume88
Issue number24
DOIs
StatePublished - Jan 1 2016

ASJC Scopus subject areas

  • Analytical Chemistry

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