Die Optimierung der Wellenform und der Porengröße des Polyurethanschwammes des Vakuumsystems

Translated title of the contribution: Waveform and foam pore size optimization of the vacuum assisted closure device

Y. I. Heit, P. Dastouri, D. L. Helm, S. S. Scherer, G. Pietramaggiori, G. Younan, D. R. Orgill

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The V.A.C.®System has become a popular device for the treatment of a variety of complex tissue defects, often based on empirical data. The objective of this study was to optimize the kinetics of V.A.C.® application and to test the impact of foam pore size. Methods: The parameters (waveform and pore size) were modified in the therapy of full-thickness wounds in diabetic mice. Wound closure and tissue response were quantitatively evaluated by macroscopic, histological and immunohistochemical analyses. Results: The continuous and sinusoidal waveform treatment induced the highest cellular proliferation rates, angiogenesis and granulation tissue depth compared to controls. Wound bed deformation was proportionally higher with the foam pore size, correlated with greater thickness of granulation tissue. Conclusions: The physical modulation has a significant impact in wound healing, while waveform modulation only causes a minor modulatory effect on granulation tissue formation, angiogenesis and proliferation in our diabetic mouse model.

Translated title of the contributionWaveform and foam pore size optimization of the vacuum assisted closure device
Original languageGerman
Pages (from-to)12-16
Number of pages5
JournalZeitschrift fur Wundheilung
Volume15
Issue numberA
StatePublished - Jun 8 2010

Keywords

  • Murine model
  • Pore size
  • V.A.C.® therapy
  • Waveform

ASJC Scopus subject areas

  • Surgery
  • Dermatology
  • Nursing (miscellaneous)

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