Watery diarrhea syndrome in an adult with ganglioneuroma‐pheochromocytoma. Identification of vasoactive intestinal peptide, calcitonin, and catecholamines and assessment of their biologic activity

Donald L. Trump, James N. Livingston, Stephen B. Baylin

Research output: Contribution to journalArticlepeer-review

Abstract

A case of adult ganglioneuroma‐pheochromocytoma with an associated watery diarrhea syndrome is reported. High levels of vasoactive intestinal peptide (VIP) were found in preoperative serum and in tumor tissue. The serum VIP levels fell to normal, and the watery diarrhea syndrome completely ceased following removal of the tumor. In addition to containing VIP, the tumor was rich in catecholamines, and calcitonin. Peptide hormone‐containing extracts and catecholamine extracts from the tumor both activated the adenyl cyclase system and increased lipolytic activity in a preparation of isolated rat fat cells. The findings in this patient further link VIP with neural crest tissues, and suggest the importance of determining catecholamine levels in patients with the watery diarrhea syndrome.

Original languageEnglish (US)
Pages (from-to)1526-1532
Number of pages7
JournalCancer
Volume40
Issue number4
DOIs
StatePublished - Oct 1977

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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