Water-soluble porphyrin-phosphonate conjugates as potential photodynamic therapy photosensitizers

Yunguo Lu, Zhihang Chen, Bingqiong Yu, Kun Yan, Zaoying Li

Research output: Contribution to journalArticlepeer-review

Abstract

Two novel water-soluble porphyrin-phosphonate conjugates were synthesized and characterized. Although both conjugates showed significant potential in photodynamic therapy, the variety of their structure induced the obvious differences in the binding manner with calf thymus DNA, the cytotoxicity and the cellular sublocalization.

Original languageEnglish (US)
Pages (from-to)1039-1045
Number of pages7
JournalJournal of Porphyrins and Phthalocyanines
Volume19
Issue number9
DOIs
StatePublished - Sep 1 2015

Keywords

  • DNA
  • photodynamic therapy
  • photosensitizers
  • porphyrin-phosphonate conjugates

ASJC Scopus subject areas

  • Chemistry(all)

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