Water exchange-minimizing DCE-MRI protocol to detect changes in tumor vascular parameters: Effect of bevacizumab/paclitaxel combination therapy

Wenlian Zhu, Yoshinori Kato, Dmitri Artemov

Research output: Contribution to journalArticle

Abstract

Objective: The purpose of this study was to assess changes in the tumor microvasculature induced by combination antiangiogenic therapy in MCF-7 breast tumor mouse models, using a noninvasive DCE-MRI method that minimizes the effect of water exchange. Materials and methods: 3D quantitative DCE-MRI images were acquired with a heavily T 1-weighted saturation recovery gradient echo sequence with a recovery delay of 20 ms. Tumor vascular volume (VV) and vascular permeability-surface area product (PS) were obtained through a linear regression of the albumin-Gd-DTPA-enhanced dynamic image intensity on MCF-7 breast tumor mouse models treated with combination bevacizumab/paclitaxel therapy. Results: Measured tumor VV values were significantly higher than the values that have been reported previously using quantitative T 1 mapping, and are in good agreement with micro-CT (computed tomography) results reported earlier from other tumor models. A trend of decreasing tumor PS was detected in the group of MCF-7 tumor bearing mice treated with the bevacizumab/paclitaxel combination regimen. Conclusion: VV and PS maps obtained by a heavily T 1-weighted acquisition protocol revealed the large peripheral blood vessels as well as the permeable areas within the tumor. A 12-day/three-dose combination treatment of bevacizumab and paclitaxel resulted in delayed tumor growth and a trend of decreasing tumor vascular permeability surface area product.

Original languageEnglish (US)
Pages (from-to)161-170
Number of pages10
JournalMagnetic Resonance Materials in Physics, Biology and Medicine
Volume27
Issue number2
DOIs
StatePublished - Apr 2014

Keywords

  • Combination antiangiogenic therapy
  • DCE-MRI
  • Tumor vascular volume and vascular permeability
  • Water exchange

ASJC Scopus subject areas

  • Biophysics
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

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