Warm autoimmune hemolytic anemia

Research output: Contribution to journalArticle

Abstract

A 61-year-old woman presents to the emergency department reporting fatigue, increasing dyspnea, and dark urine. The respiratory rate is 30 breaths per minute, the pulse 116 beats per minute, and the oxygen saturation 90% while she is breathing ambient air. She is pale, without splenomegaly or adenopathy. Her hemoglobin level is 5.4 g per deciliter, hematocrit 16.1%, and mean corpuscular volume 103 fl; the white-cell and platelet counts are normal. The percentage of reticulocytes is 15.7%, and the total bilirubin level is 9.7 mg per deciliter (166 μ mol per liter). A peripheralblood smear reveals numerous microspherocytes. A direct antiglobulin test is positive for IgG and weakly positive for C3d. Laboratory tests show a panagglutinin. She takes no regular medication. How would you further evaluate and treat this patient?.

Original languageEnglish (US)
Pages (from-to)647-654
Number of pages8
JournalNew England Journal of Medicine
Volume381
Issue number7
DOIs
StatePublished - Aug 15 2019

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Coombs Test
Autoimmune Hemolytic Anemia
Erythrocyte Indices
Reticulocytes
Splenomegaly
Respiratory Rate
Platelet Count
Hematocrit
Bilirubin
Dyspnea
Fatigue
Hospital Emergency Service
Respiration
Hemoglobins
Cell Count
Immunoglobulin G
Air
Urine
Oxygen
Lymphadenopathy

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Warm autoimmune hemolytic anemia. / Brodsky, Robert A.

In: New England Journal of Medicine, Vol. 381, No. 7, 15.08.2019, p. 647-654.

Research output: Contribution to journalArticle

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