Warfarin prophylaxis and venous thromboembolism in the first 5 days following hip and knee arthroplasty

Daniel Brotman, Amir K. Jaffer, Jason G. Hurbanek, Nariman Morra

Research output: Contribution to journalArticle

Abstract

Many orthopaedic surgeons use warfarin to prevent venous thromboembolism (VTE) following hip or knee arthroplasty. Since warfarin's antithrombotic effects are delayed, we hypothesized that early VTE (occurring within 5 days post-operatively) would be more common in arthroplasty patients receiving warfarin monotherapy compared to those receiving enoxaparin. We performed a secondary analysis of a case-control study examining risk factors for post-operative thrombosis in postmenopausal women. We defined cases as patients who were diagnosed with thrombosis within 5 days of surgery. Controls without thrombosis were matched with cases by age, surgeon, year of surgery and surgical joint. 84 women with early post-operative thrombosis (cases) were matched with 206 controls. 18 cases (21.4%) had been prescribed warfarin monotherapy, compared with 7 controls (3.4%). 58 (69.1%) cases and 195 (94.7%) controls had been prescribed subcutaneous enoxaparin 30 mg twice daily, starting 12-24 hours after surgery. The odds ratio for any early thrombosis in patients receiving warfarin as opposed to enoxaparin 30 mg twice daily was 8.6 (p

Original languageEnglish (US)
Pages (from-to)1012-1017
Number of pages6
JournalThrombosis and Haemostasis
Volume92
Issue number5
DOIs
StatePublished - Nov 2004
Externally publishedYes

Fingerprint

Knee Replacement Arthroplasties
Venous Thromboembolism
Warfarin
Hip
Thrombosis
Enoxaparin
Ambulatory Surgical Procedures
Arthroplasty
Case-Control Studies
Joints
Odds Ratio

Keywords

  • Arthroplasty
  • Enoxaparin
  • Post-operative
  • Venous thromboembolism
  • Warfarin

ASJC Scopus subject areas

  • Hematology

Cite this

Warfarin prophylaxis and venous thromboembolism in the first 5 days following hip and knee arthroplasty. / Brotman, Daniel; Jaffer, Amir K.; Hurbanek, Jason G.; Morra, Nariman.

In: Thrombosis and Haemostasis, Vol. 92, No. 5, 11.2004, p. 1012-1017.

Research output: Contribution to journalArticle

Brotman, Daniel ; Jaffer, Amir K. ; Hurbanek, Jason G. ; Morra, Nariman. / Warfarin prophylaxis and venous thromboembolism in the first 5 days following hip and knee arthroplasty. In: Thrombosis and Haemostasis. 2004 ; Vol. 92, No. 5. pp. 1012-1017.
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