Wallerian degeneration in peripheral nerve disease

J. W. Griffin, E. B. George, V. Chaudhry

Research output: Contribution to journalReview articlepeer-review

47 Scopus citations


Wallerian-like degeneration can be regarded as the final shared pathway of the most prevalent diseases of the peripheral nervous system, including many degenerative, metabolic, heritable, toxic, inflammatory and ischaemic disorders. The cellular responses that take place during Wallerian degeneration, including the elaboration of neurotrophins, are increasingly recognized to set the stage for the success or failure of subsequent regeneration, and manipulations of Wallerian degeneration are being investigated as a potential means of altering the outcome of nerve regeneration.

Original languageEnglish (US)
Pages (from-to)65-75
Number of pages11
JournalBailliere's Clinical Neurology
Issue number1
StatePublished - May 2 1996

ASJC Scopus subject areas

  • Clinical Neurology


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