Wallerian degeneration in human nerves: Serial electrophysiological studies

Research output: Contribution to journalArticle

Abstract

After nerve transection, the distal stump undergoes Wallerian degeneration (WD). Little information is available concerning sequential changes in nerve conduction measurements during WD in humans. Five patients with nerve injuries were studied temporally. Motor-evoked amplitudes were reduced by 50% at 3 to 5 days after injury; the response was absent by day 9. Sensory-evoked amplitudes were reduced by 50% at 7 days after injury; the response was absent by day 11. Sensory and motor nerves with shorter distal stumps showed earlier loss of amplitude than did those with longer distal stumps. Denervation potentials were seen 10 to 14 days after injury. Our results suggest that WD occurs earlier if the distal stump is shorter, and that motor-evoked responses are affected earlier than sensory-evoked responses. The time-lag between the loss of the motor-evoked response and the appearance of denervation potentials, the latter coinciding with reduction of sensory evoked responses, suggests that failure of neuromuscular transmission precedes axonal loss during WD.

Original languageEnglish (US)
Pages (from-to)687-693
Number of pages7
JournalMuscle and Nerve
Volume15
Issue number6
DOIs
StatePublished - 1992

Fingerprint

Wallerian Degeneration
Wounds and Injuries
Denervation
Neural Conduction

Keywords

  • motor nerve
  • nerve conduction
  • nerve injury
  • sensory nerve
  • Wallerian degeneration

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Wallerian degeneration in human nerves : Serial electrophysiological studies. / Chaudhry, Vinay; Cornblath, David.

In: Muscle and Nerve, Vol. 15, No. 6, 1992, p. 687-693.

Research output: Contribution to journalArticle

@article{98adec825a0c43b2897e4a7d20050431,
title = "Wallerian degeneration in human nerves: Serial electrophysiological studies",
abstract = "After nerve transection, the distal stump undergoes Wallerian degeneration (WD). Little information is available concerning sequential changes in nerve conduction measurements during WD in humans. Five patients with nerve injuries were studied temporally. Motor-evoked amplitudes were reduced by 50{\%} at 3 to 5 days after injury; the response was absent by day 9. Sensory-evoked amplitudes were reduced by 50{\%} at 7 days after injury; the response was absent by day 11. Sensory and motor nerves with shorter distal stumps showed earlier loss of amplitude than did those with longer distal stumps. Denervation potentials were seen 10 to 14 days after injury. Our results suggest that WD occurs earlier if the distal stump is shorter, and that motor-evoked responses are affected earlier than sensory-evoked responses. The time-lag between the loss of the motor-evoked response and the appearance of denervation potentials, the latter coinciding with reduction of sensory evoked responses, suggests that failure of neuromuscular transmission precedes axonal loss during WD.",
keywords = "motor nerve, nerve conduction, nerve injury, sensory nerve, Wallerian degeneration",
author = "Vinay Chaudhry and David Cornblath",
year = "1992",
doi = "10.1002/mus.880150610",
language = "English (US)",
volume = "15",
pages = "687--693",
journal = "Muscle and Nerve",
issn = "0148-639X",
publisher = "John Wiley and Sons Inc.",
number = "6",

}

TY - JOUR

T1 - Wallerian degeneration in human nerves

T2 - Serial electrophysiological studies

AU - Chaudhry, Vinay

AU - Cornblath, David

PY - 1992

Y1 - 1992

N2 - After nerve transection, the distal stump undergoes Wallerian degeneration (WD). Little information is available concerning sequential changes in nerve conduction measurements during WD in humans. Five patients with nerve injuries were studied temporally. Motor-evoked amplitudes were reduced by 50% at 3 to 5 days after injury; the response was absent by day 9. Sensory-evoked amplitudes were reduced by 50% at 7 days after injury; the response was absent by day 11. Sensory and motor nerves with shorter distal stumps showed earlier loss of amplitude than did those with longer distal stumps. Denervation potentials were seen 10 to 14 days after injury. Our results suggest that WD occurs earlier if the distal stump is shorter, and that motor-evoked responses are affected earlier than sensory-evoked responses. The time-lag between the loss of the motor-evoked response and the appearance of denervation potentials, the latter coinciding with reduction of sensory evoked responses, suggests that failure of neuromuscular transmission precedes axonal loss during WD.

AB - After nerve transection, the distal stump undergoes Wallerian degeneration (WD). Little information is available concerning sequential changes in nerve conduction measurements during WD in humans. Five patients with nerve injuries were studied temporally. Motor-evoked amplitudes were reduced by 50% at 3 to 5 days after injury; the response was absent by day 9. Sensory-evoked amplitudes were reduced by 50% at 7 days after injury; the response was absent by day 11. Sensory and motor nerves with shorter distal stumps showed earlier loss of amplitude than did those with longer distal stumps. Denervation potentials were seen 10 to 14 days after injury. Our results suggest that WD occurs earlier if the distal stump is shorter, and that motor-evoked responses are affected earlier than sensory-evoked responses. The time-lag between the loss of the motor-evoked response and the appearance of denervation potentials, the latter coinciding with reduction of sensory evoked responses, suggests that failure of neuromuscular transmission precedes axonal loss during WD.

KW - motor nerve

KW - nerve conduction

KW - nerve injury

KW - sensory nerve

KW - Wallerian degeneration

UR - http://www.scopus.com/inward/record.url?scp=0026632676&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026632676&partnerID=8YFLogxK

U2 - 10.1002/mus.880150610

DO - 10.1002/mus.880150610

M3 - Article

C2 - 1324426

AN - SCOPUS:0026632676

VL - 15

SP - 687

EP - 693

JO - Muscle and Nerve

JF - Muscle and Nerve

SN - 0148-639X

IS - 6

ER -