Vulvar Lesions in an 8-Year-Old Girl: Cutaneous Manifestations of Multisystem Langerhans Cell Histiocytosis

Elisa M. Jorgensen, Peter P. Chen, Sarah Rutter, Julia A. Cron

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Langerhans cell histiocytosis (LCH) is a rare localized or systemic disease characterized by proliferation of myeloid-derived dendritic cells. Vulvar lesions might be the herald symptom of LCH and might mimic other cutaneous lesions. Prognosis varies widely on the basis of the extent and spread of disease. Case: An 8-year-old girl with a 4-month history of vulvar lesions resistant to topical steroids was referred by her pediatrician. Vulvar biopsy was diagnostic for LCH. Imaging studies revealed a left hip lesion consistent with LCH. The patient was subsequently treated for multisystem LCH with vinblastine and prednisone. Summary and Conclusion: Although rare, LCH might be diagnosed by gynecologic providers and should be included in the differential diagnosis of genital lesions. We recommend having a low threshold for performing biopsy of vulvar lesions.

Original languageEnglish (US)
Pages (from-to)153-155
Number of pages3
JournalJournal of pediatric and adolescent gynecology
Volume31
Issue number2
DOIs
StatePublished - Apr 2018
Externally publishedYes

Keywords

  • LCH
  • Langerhans cell histiocytosis
  • Vulva
  • Vulvar lesion

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

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