Vulvar condylomas and squamous vestibular micropapilloma: Differences in appearance and response to treatment

R. K. Potkul, W. D. Lancaster, R. J. Kurman, G. Lewandowski, P. K. Weck, G. Delgado

Research output: Contribution to journalArticlepeer-review

Abstract

A study of 37 women with typical condylomas and so-called squamous micropapilloma was undertaken to determine their response to systemic interferon and/or podophyllin treatment. Thirty lesions were classified as condylomas and 9 as squamous micropapillomas; two women had both lesions. Twenty-six (87%) of 30 condylomas responded, whereas only 1 (11%) of the 9 cases of micropapillomatosis showed a partial response (P < .001) to podophyllin and/or interferon. Twenty-six biopsies from condylomas in which sufficient DNA was available for analysis contained human papillomavirus (HPV) DNA sequences that hybridized to an HPV 6 + 16 probe mix under nonstringent conditions. In contrast, HPV DNA sequences could not be detected in any of the nine cases of micropapillomatosis. Immunoperoxidase studies performed on these lesions failed to demonstrate viral capsid antigen. Thus, despite certain similarities in the clinical presentation and microscopic features of condylomas and squamous micropapillomas, it is not clear at present whether micropapillomas are HPV-related lesions.

Original languageEnglish (US)
Pages (from-to)1019-1022
Number of pages4
JournalJournal of Reproductive Medicine for the Obstetrician and Gynecologist
Volume35
Issue number11
StatePublished - Dec 1 1990
Externally publishedYes

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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