Voxel based morphometry in optical coherence tomography: Validation & core findings

Bhavna J. Antony, Min Chen, Aaron Carass, Bruno M. Jedynak, Omar Al-Louzi, Sharon Solomon, Shiv Saidha, Peter Calabresi, Jerry Ladd Prince

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Optical coherence tomography (OCT) of the human retina is now becoming established as an important modality for the detection and tracking of various ocular diseases. Voxel based morphometry (VBM) is a long standing neuroimaging analysis technique that allows for the exploration of the regional differences in the brain. There has been limited work done in developing registration based methods for OCT, which has hampered the advancement of VBM analyses in OCT based population studies. Following on from our recent development of an OCT registration method, we explore the potential benefits of VBM analysis in cohorts of healthy controls (HCs) and multiple sclerosis (MS) patients. Specifically, we validate the stability of VBM analysis in two pools of HCs showing no significant difference between the two populations. Additionally, we also present a retrospective study of age and sex matched HCs and relapsing remitting MS patients, demonstrating results consistent with the reported literature while providing insight into the retinal changes associated with this MS subtype.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2016: Biomedical Applications in Molecular, Structural, and Functional Imaging
PublisherSPIE
Volume9788
ISBN (Electronic)9781510600232
DOIs
StatePublished - 2016
EventMedical Imaging 2016: Biomedical Applications in Molecular, Structural, and Functional Imaging - San Diego, United States
Duration: Mar 1 2016Mar 3 2016

Other

OtherMedical Imaging 2016: Biomedical Applications in Molecular, Structural, and Functional Imaging
CountryUnited States
CitySan Diego
Period3/1/163/3/16

Fingerprint

Optical tomography
Optical Coherence Tomography
tomography
Multiple Sclerosis
Neuroimaging
Relapsing-Remitting Multiple Sclerosis
Eye Diseases
retina
Population
brain
Retina
Brain
Cohort Studies
Retrospective Studies

Keywords

  • Multiple sclerosis
  • Normalized atlas
  • Optical coherence tomography
  • RAVENS
  • Registration
  • Retina
  • Voxel-based morphometry

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Antony, B. J., Chen, M., Carass, A., Jedynak, B. M., Al-Louzi, O., Solomon, S., ... Prince, J. L. (2016). Voxel based morphometry in optical coherence tomography: Validation & core findings. In Medical Imaging 2016: Biomedical Applications in Molecular, Structural, and Functional Imaging (Vol. 9788). [97880P] SPIE. https://doi.org/10.1117/12.2216096

Voxel based morphometry in optical coherence tomography : Validation & core findings. / Antony, Bhavna J.; Chen, Min; Carass, Aaron; Jedynak, Bruno M.; Al-Louzi, Omar; Solomon, Sharon; Saidha, Shiv; Calabresi, Peter; Prince, Jerry Ladd.

Medical Imaging 2016: Biomedical Applications in Molecular, Structural, and Functional Imaging. Vol. 9788 SPIE, 2016. 97880P.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Antony, BJ, Chen, M, Carass, A, Jedynak, BM, Al-Louzi, O, Solomon, S, Saidha, S, Calabresi, P & Prince, JL 2016, Voxel based morphometry in optical coherence tomography: Validation & core findings. in Medical Imaging 2016: Biomedical Applications in Molecular, Structural, and Functional Imaging. vol. 9788, 97880P, SPIE, Medical Imaging 2016: Biomedical Applications in Molecular, Structural, and Functional Imaging, San Diego, United States, 3/1/16. https://doi.org/10.1117/12.2216096
Antony BJ, Chen M, Carass A, Jedynak BM, Al-Louzi O, Solomon S et al. Voxel based morphometry in optical coherence tomography: Validation & core findings. In Medical Imaging 2016: Biomedical Applications in Molecular, Structural, and Functional Imaging. Vol. 9788. SPIE. 2016. 97880P https://doi.org/10.1117/12.2216096
Antony, Bhavna J. ; Chen, Min ; Carass, Aaron ; Jedynak, Bruno M. ; Al-Louzi, Omar ; Solomon, Sharon ; Saidha, Shiv ; Calabresi, Peter ; Prince, Jerry Ladd. / Voxel based morphometry in optical coherence tomography : Validation & core findings. Medical Imaging 2016: Biomedical Applications in Molecular, Structural, and Functional Imaging. Vol. 9788 SPIE, 2016.
@inproceedings{123797464b0c4471a70c31623cc06489,
title = "Voxel based morphometry in optical coherence tomography: Validation & core findings",
abstract = "Optical coherence tomography (OCT) of the human retina is now becoming established as an important modality for the detection and tracking of various ocular diseases. Voxel based morphometry (VBM) is a long standing neuroimaging analysis technique that allows for the exploration of the regional differences in the brain. There has been limited work done in developing registration based methods for OCT, which has hampered the advancement of VBM analyses in OCT based population studies. Following on from our recent development of an OCT registration method, we explore the potential benefits of VBM analysis in cohorts of healthy controls (HCs) and multiple sclerosis (MS) patients. Specifically, we validate the stability of VBM analysis in two pools of HCs showing no significant difference between the two populations. Additionally, we also present a retrospective study of age and sex matched HCs and relapsing remitting MS patients, demonstrating results consistent with the reported literature while providing insight into the retinal changes associated with this MS subtype.",
keywords = "Multiple sclerosis, Normalized atlas, Optical coherence tomography, RAVENS, Registration, Retina, Voxel-based morphometry",
author = "Antony, {Bhavna J.} and Min Chen and Aaron Carass and Jedynak, {Bruno M.} and Omar Al-Louzi and Sharon Solomon and Shiv Saidha and Peter Calabresi and Prince, {Jerry Ladd}",
year = "2016",
doi = "10.1117/12.2216096",
language = "English (US)",
volume = "9788",
booktitle = "Medical Imaging 2016: Biomedical Applications in Molecular, Structural, and Functional Imaging",
publisher = "SPIE",

}

TY - GEN

T1 - Voxel based morphometry in optical coherence tomography

T2 - Validation & core findings

AU - Antony, Bhavna J.

AU - Chen, Min

AU - Carass, Aaron

AU - Jedynak, Bruno M.

AU - Al-Louzi, Omar

AU - Solomon, Sharon

AU - Saidha, Shiv

AU - Calabresi, Peter

AU - Prince, Jerry Ladd

PY - 2016

Y1 - 2016

N2 - Optical coherence tomography (OCT) of the human retina is now becoming established as an important modality for the detection and tracking of various ocular diseases. Voxel based morphometry (VBM) is a long standing neuroimaging analysis technique that allows for the exploration of the regional differences in the brain. There has been limited work done in developing registration based methods for OCT, which has hampered the advancement of VBM analyses in OCT based population studies. Following on from our recent development of an OCT registration method, we explore the potential benefits of VBM analysis in cohorts of healthy controls (HCs) and multiple sclerosis (MS) patients. Specifically, we validate the stability of VBM analysis in two pools of HCs showing no significant difference between the two populations. Additionally, we also present a retrospective study of age and sex matched HCs and relapsing remitting MS patients, demonstrating results consistent with the reported literature while providing insight into the retinal changes associated with this MS subtype.

AB - Optical coherence tomography (OCT) of the human retina is now becoming established as an important modality for the detection and tracking of various ocular diseases. Voxel based morphometry (VBM) is a long standing neuroimaging analysis technique that allows for the exploration of the regional differences in the brain. There has been limited work done in developing registration based methods for OCT, which has hampered the advancement of VBM analyses in OCT based population studies. Following on from our recent development of an OCT registration method, we explore the potential benefits of VBM analysis in cohorts of healthy controls (HCs) and multiple sclerosis (MS) patients. Specifically, we validate the stability of VBM analysis in two pools of HCs showing no significant difference between the two populations. Additionally, we also present a retrospective study of age and sex matched HCs and relapsing remitting MS patients, demonstrating results consistent with the reported literature while providing insight into the retinal changes associated with this MS subtype.

KW - Multiple sclerosis

KW - Normalized atlas

KW - Optical coherence tomography

KW - RAVENS

KW - Registration

KW - Retina

KW - Voxel-based morphometry

UR - http://www.scopus.com/inward/record.url?scp=84978891234&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84978891234&partnerID=8YFLogxK

U2 - 10.1117/12.2216096

DO - 10.1117/12.2216096

M3 - Conference contribution

C2 - 27199503

AN - SCOPUS:84978891234

VL - 9788

BT - Medical Imaging 2016: Biomedical Applications in Molecular, Structural, and Functional Imaging

PB - SPIE

ER -