Von willebrand factor and the right ventricle (the MESA-right ventricle study)

Peter J. Leary, R. Graham Barr, David A. Bluemke, Michael R. Bristow, Catherine L. Hough, Richard A. Kronmal, Joao Lima, Robyn L. McClelland, Russell P. Tracy, Steven M. Kawut

Research output: Contribution to journalArticle

Abstract

Elevation in plasma activity of von Willebrand factor (vWF) reflects endothelial dysfunction and predicts death in pulmonary arterial hypertension. Higher vWF activity is also associated with a lower right ventricular (RV) ejection fraction in pulmonary arterial hypertension. Little is known about the relation between vWF and RV structure and function in adults without cardiovascular disease. The present investigation included 1,976 participants with magnetic resonance imaging assessment of RV structure and function and measurement of vWF activity from the Multi-Ethnic Study of Atherosclerosis. Multivariable linear regression was used to estimate the associations between vWF activity and measures of RV structure and function after adjusting for demographics, anthropometrics, smoking, diabetes mellitus, hypertension, and the corresponding left ventricular parameter. The average vWF activity was 140.7 ± 57.2%. Elevated vWF activity was independently associated with lower RV mass, RV end-diastolic volume, and RV stroke volume in models with and without adjustment for the corresponding left ventricular parameter (all p values

Original languageEnglish (US)
Pages (from-to)1846-1851
Number of pages6
JournalThe American Journal of Cardiology
Volume110
Issue number12
DOIs
StatePublished - Dec 15 2012

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von Willebrand Factor
Heart Ventricles
Right Ventricular Function
Stroke Volume
Pulmonary Hypertension
Linear Models
Atherosclerosis
Diabetes Mellitus
Cardiovascular Diseases
Smoking
Magnetic Resonance Imaging
Demography
Hypertension

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Leary, P. J., Barr, R. G., Bluemke, D. A., Bristow, M. R., Hough, C. L., Kronmal, R. A., ... Kawut, S. M. (2012). Von willebrand factor and the right ventricle (the MESA-right ventricle study). The American Journal of Cardiology, 110(12), 1846-1851. https://doi.org/10.1016/j.amjcard.2012.08.022

Von willebrand factor and the right ventricle (the MESA-right ventricle study). / Leary, Peter J.; Barr, R. Graham; Bluemke, David A.; Bristow, Michael R.; Hough, Catherine L.; Kronmal, Richard A.; Lima, Joao; McClelland, Robyn L.; Tracy, Russell P.; Kawut, Steven M.

In: The American Journal of Cardiology, Vol. 110, No. 12, 15.12.2012, p. 1846-1851.

Research output: Contribution to journalArticle

Leary, PJ, Barr, RG, Bluemke, DA, Bristow, MR, Hough, CL, Kronmal, RA, Lima, J, McClelland, RL, Tracy, RP & Kawut, SM 2012, 'Von willebrand factor and the right ventricle (the MESA-right ventricle study)', The American Journal of Cardiology, vol. 110, no. 12, pp. 1846-1851. https://doi.org/10.1016/j.amjcard.2012.08.022
Leary PJ, Barr RG, Bluemke DA, Bristow MR, Hough CL, Kronmal RA et al. Von willebrand factor and the right ventricle (the MESA-right ventricle study). The American Journal of Cardiology. 2012 Dec 15;110(12):1846-1851. https://doi.org/10.1016/j.amjcard.2012.08.022
Leary, Peter J. ; Barr, R. Graham ; Bluemke, David A. ; Bristow, Michael R. ; Hough, Catherine L. ; Kronmal, Richard A. ; Lima, Joao ; McClelland, Robyn L. ; Tracy, Russell P. ; Kawut, Steven M. / Von willebrand factor and the right ventricle (the MESA-right ventricle study). In: The American Journal of Cardiology. 2012 ; Vol. 110, No. 12. pp. 1846-1851.
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