Von willebrand factor and the right ventricle (the MESA-right ventricle study)

Peter J. Leary, R. Graham Barr, David A. Bluemke, Michael R. Bristow, Catherine L. Hough, Richard A. Kronmal, Joao A. Lima, Robyn L. McClelland, Russell P. Tracy, Steven M. Kawut

Research output: Contribution to journalArticle

Abstract

Elevation in plasma activity of von Willebrand factor (vWF) reflects endothelial dysfunction and predicts death in pulmonary arterial hypertension. Higher vWF activity is also associated with a lower right ventricular (RV) ejection fraction in pulmonary arterial hypertension. Little is known about the relation between vWF and RV structure and function in adults without cardiovascular disease. The present investigation included 1,976 participants with magnetic resonance imaging assessment of RV structure and function and measurement of vWF activity from the Multi-Ethnic Study of Atherosclerosis. Multivariable linear regression was used to estimate the associations between vWF activity and measures of RV structure and function after adjusting for demographics, anthropometrics, smoking, diabetes mellitus, hypertension, and the corresponding left ventricular parameter. The average vWF activity was 140.7 ± 57.2%. Elevated vWF activity was independently associated with lower RV mass, RV end-diastolic volume, and RV stroke volume in models with and without adjustment for the corresponding left ventricular parameter (all p values <0.05). There was no association observed between vWF activity and the RV ejection fraction. In conclusion, higher vWF activity is associated with lower RV mass, RV end-diastolic volume, and RV stroke volume. These associations are independent of common cardiovascular risk factors and left ventricular morphologic changes.

Original languageEnglish (US)
Pages (from-to)1846-1851
Number of pages6
JournalAmerican Journal of Cardiology
Volume110
Issue number12
DOIs
StatePublished - Dec 15 2012

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Von willebrand factor and the right ventricle (the MESA-right ventricle study)'. Together they form a unique fingerprint.

  • Cite this

    Leary, P. J., Barr, R. G., Bluemke, D. A., Bristow, M. R., Hough, C. L., Kronmal, R. A., Lima, J. A., McClelland, R. L., Tracy, R. P., & Kawut, S. M. (2012). Von willebrand factor and the right ventricle (the MESA-right ventricle study). American Journal of Cardiology, 110(12), 1846-1851. https://doi.org/10.1016/j.amjcard.2012.08.022